• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>EBioMedicine >Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugs
【24h】

Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugs

机译：用直接作用抗丙型肝炎病毒药物治疗后基因组不稳定增加

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mixed Cryoglobulinemic Vasculitis (MCV) is a prominent extra-hepatic manifestation of Hepatitis C virus (HCV) infection. HCV has been reported to cause B-cell disorders and genomic instability. Here, we investigated B-cell activation and genome stability in HCV-MCV patients receiving the direct antiviral agent, Sofosbuvir, at multiple centers in Egypt. Clinical manifestations in HCV-MCV patients were improved at the end of treatment (EOT), such as purpura (100%), articular manifestations (75%) and neuropathy (68%). Eighteen patients (56%) showed vasculitis relapse after EOT. BAFF and APRIL were higher at EOT and continued to increase one year following treatment onset. Chromosomal breaks were elevated at EOT compared to baseline levels and were sustained at 3 and 6?months post treatment. We report increased expression of DNA genome stability transcripts such as topoisomerase 1 and TDP1 in HCV-MCV patients after treatment, which continued to increase at 12?months from treatment onset. This data suggest that B-cell activation and DNA damage are important determinants of HCV-MCV treatment outcomes.
机译：混合低温球囊血管炎（MCV）是丙型肝炎病毒（HCV）感染的主要肝外表现。据报道，HCV会引起B细胞疾病和基因组不稳定。在这里，我们调查了埃及多个中心接受直接抗病毒药物Sofosbuvir的HCV-MCV患者的B细胞活化和基因组稳定性。 HCV-MCV患者的临床表现在治疗结束时（EOT）有所改善，例如紫癜（100％），关节表现（75％）和神经病变（68％）。 EOT后有18例患者（56％）出现血管炎复发。 BAFF和APRIL在EOT时较高，并且在治疗开始一年后继续增加。与基线水平相比，EOT处的染色体断裂增加，并在治疗后3和6个月持续。我们报道治疗​​后HCV-MCV患者的DNA基因组稳定转录本（例如拓扑异构酶1和TDP1）的表达增加，从治疗开始的12个月持续增加。该数据表明，B细胞活化和DNA损伤是HCV-MCV治疗结果的重要决定因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号