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Brain changes in social anxiety disorder run in the family

机译：家庭中社交焦虑症的大脑变化

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Social anxiety disorder (SAD) is a prevalent and costly psychiatriccondition that causes great suffering for afflicted individuals [4]. Centralfor SAD is the fear of being evaluated, and social situations are eitheravoided or endured with great anxiety. The current treatment optionsleave a large proportion still suffering. Thus, proper understanding ofthe etiological processes leading to SAD is important for developmentof novel treatments and prevention strategies. An important contributionto this end is the first report of structural brain alterations suggestedto be candidate endophenotypes for SAD by Bas-Hoogendamand colleagues in this issue of EBioMedicine [1,2]. The authors useddata from the innovative multiplex, multigenerational Leiden FamilyLab Study on Social Anxiety Disorder including 110 participants,consisting of those with SAD and unaffected family members from 8families genetically enriched for SAD [2]. Heritability estimates ofthree measures of brain morphology were derived from anatomicalT1-weightedmagnetic resonance images.Moderate-to-high heritabilityof SAD-associated morphological changes was found in the volume ofthe globus pallidus, cortical thickness in frontal and temporal regions,as well as the cortical surface area of the fusiform gyrus.
机译：社交焦虑症（SAD）是一种普遍存在且代价高昂的精神病，会给患病个体带来巨大痛苦[4]。 Centralfor SAD害怕被评估，社会状况得以避免或遭受极大的焦虑。当前的治疗方案仍然使很大一部分人遭受痛苦。因此，正确理解导致SAD的病因过程对于开发新的治疗方法和预防策略很重要。为此目的的重要贡献是Bas-Hoogendamand及其同事在本期EBioMedicine [1,2]中首次提出结构性大脑改变被认为是SAD的候选内表型的报道。作者使用了创新的多元，多代莱顿家庭实验室社会焦虑症研究的数据，其中包括110名参与者，其中包括SAD者和来自8个基因丰富的SAD家族的未受影响家庭成员[2]。从解剖T1加权磁共振图像中得出了三种大脑形态学测量值的遗传力估计值。苍白球的体积，额叶和颞叶区域的皮质厚度以及皮质表面均发现了与SAD相关的形态学变化的中等至高遗传率。梭状回的区域。

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