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首页> 外文期刊>e-Jurnal Medika Udayana >METHYLMALONIC ACID AND HOMOCYSTEIN SERUM IN DIAGNOSING MEGALOBLASTIC ANEMIA DUE TO COBALAMIN AND FOLATE DEFICIENCY IN TRAVEL MEDICINE
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METHYLMALONIC ACID AND HOMOCYSTEIN SERUM IN DIAGNOSING MEGALOBLASTIC ANEMIA DUE TO COBALAMIN AND FOLATE DEFICIENCY IN TRAVEL MEDICINE

机译：诊断氨基甲酸酯和叶酸缺乏的甲基丙二酸和同型半胱氨酸血清可诊断成胚细胞性贫血

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Normal 0 false false false EN-US X-NONE X-NONE Anemia is a major global health problem, especially in developing countries. Anemia is a condition where the red blood cell mass and / or hemoglobin mass that circulating in the body was decreased to below normal level so it can not function well in providing oxygen to the body tissues . One of the most common type is megaloblastic anemia. Megaloblastic anemia is mostly caused by vitamin B 12 (cobalamin) and folate deficiency. One of the causes of cobalamin and folate deficiency anemia is tropical sprue. Cobalamin deficiency anemia and folate deficiency anemia gives a similar symptom, but in cobalamin deficiency there is neuropathy symptoms. Normal serum folate is between 3-15 ng/mL. Normal folate erythrocyte is 150-600 ng/mL. In cobalamin deficiency, serum cobalamin decreased below the cut off point 100pg/mL (normally 100 - 400pg/mL). Other examination such as elevated homocysteine ?? , methylmalonic acid, or formioglutamic acid (FIGLU) in the urine can confirm the diagnosis of cobalamin and folic acid deficiency. There is no consensus on the cut-off point of homocysteine ?? and MMA. Homocysteine ?? has been considered to increase when the levels are above 12-14 ?mol /L in women and in the 14-15 ?mol/L. According to research by Robert et al in the case of cobalamin deficiency, serum tHcy> 15.0 ?mol/L. Most research considers the increase of MMA in cobalamin deficiency is> 0:28 ?mol / L, but the cut off point in circulation varies between 0:21 to 0:48 ?mol/L. MMA level is increased in serum and urine in cobalamin deficiency, whereas MMA normal in folate deficiency. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}
机译：正常0错误错误错误EN-US X-NONE X-NONE贫血是全球主要的健康问题，尤其是在发展中国家。贫血是指体内循环的红细胞和/或血红蛋白量减少到正常水平以下，因此不能很好地为身体组织提供氧气。最常见的类型之一是巨幼细胞性贫血。巨幼细胞性贫血主要由维生素B 12（钴胺素）和叶酸缺乏引起。钴胺素和叶酸缺乏性贫血的原因之一是热带浇注。钴胺素缺乏症贫血和叶酸缺乏症贫血的症状相似，但钴胺素缺乏症有神经病症状。正常的血清叶酸为3-15 ng / mL。正常的叶酸红细胞为150-600 ng / mL。在钴胺素缺乏症中，血清钴胺素降低到临界值100pg / mL以下（通常为100-400pg / mL）。其他检查，例如高半胱氨酸升高尿中的甲基丙二酸或甲谷氨酸（FIGLU）可以确诊钴胺素和叶酸缺乏症。关于高半胱氨酸的临界点尚未达成共识。和MMA。同型半胱氨酸当女性的水平高于12-14μmol/ L时，以及14-15μmol/ L时，已被认为增加。根据Robert等人在钴胺素缺乏症的研究中，血清tHcy> 15.0μmol/ L。大多数研究认为钴胺素缺乏症中MMA的增加> 0:28μmol/ L，但循环的临界点在0:21至0:48μmol/ L之间变化。钴胺素缺乏症患者血清和尿液中MMA水平升高，而叶酸缺乏症患者MMA水平正常。 / *样式定义* / table.MsoNormalTable {mso-style-name：“ Table Normal”; mso-tstyle-rowband-size：0; mso-tstyle-colband-size：0; mso-style-noshow：是; mso-style-priority：99; mso-style-qformat：是; mso-style-parent：“”; mso-padding-alt：0in 5.4pt 0in 5.4pt; mso-para-margin：0in; mso-para-margin-bottom：.0001pt; mso分页：寡妇孤儿;字体大小：11.0pt;字体家族：“ Calibri”，“ sans-serif”; mso-ascii-font-family：Calibri; mso-ascii-theme-font：minor-latin; mso-fareast-font-family：“时代新罗马”; mso-fareast-主题字体：minor-fareast; mso-hansi-font-family：Calibri; mso-hansi-theme-font：minor-latin; mso-bidi-font-family：“时代新罗马”; mso-bidi-theme-font：minor-bidi;}

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