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首页> 外文期刊>EBioMedicine >Risk of All-Cause Mortality in Alcohol-Dependent Individuals: A Systematic Literature Review and Meta-Analysis
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Risk of All-Cause Mortality in Alcohol-Dependent Individuals: A Systematic Literature Review and Meta-Analysis

机译：酒精依赖者全因死亡率的风险：系统的文献综述和荟萃分析

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Background: Alcohol dependence (AD) carries a high mortality burden, which may be mitigated by reduced alcohol consumption. We conducted a systematic literature review and meta-analysis investigating the risk of all-cause mortality in alcohol-dependent subjects. Methods: MEDLINE, MEDLINE In-Process, Embase and PsycINFO were searched from database conception through 26th June 2014. Eligible studies reported all-cause mortality in both alcohol-dependent subjects and a comparator population of interest. Two individuals independently reviewed studies. Of 4540 records identified, 39 observational studies were included in meta-analyses. Findings: We identified a significant increase in mortality for alcohol-dependent subjects compared with the general population (27 studies; relative risk [RR]=3.45; 95% CI [2.96, 4.02]; p<0.0001). The mortality increase was also significant compared to subjects qualifying for a diagnosis of alcohol abuse or subjects without alcohol use disorders (AUDs). Alcohol-dependent subjects continuing to drink heavily had significantly greater mortality than alcohol-dependent subjects who reduced alcohol intake, even if abstainers were excluded (p<0.05). Interpretation: AD was found to significantly increase an individual's risk of all-cause mortality. While abstinence in alcohol-dependent subjects led to greater mortality reduction than non-abstinence, this study suggests that alcohol-dependent subjects can significantly reduce their mortality risk by reducing alcohol consumption.
机译：背景：酒精依赖症（AD）带来很高的死亡率负担，可以通过减少酒精消耗量来缓解。我们进行了系统的文献综述和荟萃分析，调查了酒精依赖者全因死亡的风险。方法：从数据库概念到2014年6月26日，搜索MEDLINE，MEDLINE In-Process，Embase和PsycINFO。合格的研究报告了酒精依赖受试者和感兴趣的比较人群的全因死亡率。两个人独立审查研究。在确定的4540条记录中，有39项观察性研究纳入了荟萃分析。结果：与普通人群相比，我们发现酒精依赖者的死亡率显着增加（27项研究;相对风险[RR] = 3.45; 95％CI [2.96，4.02]; p <0.0001）。与符合酒精滥用诊断资格或无酒精使用障碍（AUDs）的受试者相比，死亡率增加也很明显。即使排除了戒酒者，继续大量饮酒的依赖酒精的受试者的死亡率也比减少饮酒的依赖酒精的受试者的死亡率明显更高（p <0.05）。解释：发现AD会显着增加个体全因死亡率的风险。虽然戒酒对酒精依赖的受试者比不戒酒导致更大的死亡率降低，但这项研究表明，戒酒依赖的受试者可以通过减少饮酒量来显着降低其死亡风险。

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