FINASTERIDE AS A TREATMENT FOR MALE ANDROGENETIC ALOPECIA

Tristiana Dewi; Ni Komang; Sugiritama; I Wyn.

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FINASTERIDE AS A TREATMENT FOR MALE ANDROGENETIC ALOPECIA

机译：非那雄胺作为男性雄激素性白内障的治疗方法

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Androgenetic alopecia (AGA) is a type of alopecia non sikatrik that most often occur, especially in men. AGA is hereditary baldness and form distinctive patterns. Causes related to AGA estimated serum androgen levels, especially 5-?-dehydrotestosterone (DHT), which can lead to miniaturization of the hair follicle. Finasteride is one of drugs that proven effective in treating hair loss caused by AGA. Finasteride is a 4-azasteroid components that are competitive and specific inhibitor of the enzyme 5-?-reductase type II, an enzyme that converts testosteron into intracellular DHT. By inhibiting the enzyme 5-?-reductase type II, conversion of testosteron to DHT inhibited, thereby causing a significant decrease in serum and tissue DHT concentrations. The use of finasteride 1 mg per day proven to effectively treat AGA in men.

机译：雄激素性脱发（AGA）是最常见的一种非脱发性脱发，特别是在男性中。 AGA是遗传性秃发，并形成独特的图案。与AGA估计的血清雄激素水平有关的原因，尤其是5-α-脱氢睾丸激素（DHT），可能导致毛囊微型化。非那雄胺是经证实可有效治疗AGA引起的脱发的药物之一。非那雄胺是一种4-氮杂甾类成分，是II型酶5-α-还原酶（一种将睾丸激素转化为细胞内DHT的酶）的竞争性特异性抑制剂。通过抑制II型5-α-还原酶，抑制了睾丸激素向DHT的转化，从而导致血清和组织中DHT浓度的显着降低。每天使用1 mg非那雄胺被证明可有效治疗男性AGA。

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《e-Jurnal Medika Udayana》 |2013年第4期|共13页
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Tristiana Dewi; Ni Komang; Sugiritama; I Wyn.;
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1. A randomized, double‐blind controlled study of the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil vs. 3% minoxidil solution in the treatment of male androgenetic alopecia [J] . Suchonwanit P., Srisuwanwattana P., Chalermroj N., Journal of the European Academy of Dermatology and Venereology: JEADV . 2018,第12期

机译：随机，双盲对照研究0.25％的小甾醇与3％米诺伊唑酯与3％明氧基硅溶液混合的局部溶液的疗效和安全性在治疗雄性和生殖血症
2. A randomized, double‐blind controlled study of the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil vs. 3% minoxidil solution in the treatment of male androgenetic alopecia [J] . Suchonwanit P., Srisuwanwattana P., Chalermroj N., Journal of the European Academy of Dermatology and Venereology: JEADV . 2018,第Suppla1期

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3. A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia [J] . GubelinHarchaW., BarbozaMartínezJ., TsaiT.-F., Journal of the American Academy of Dermatology . 2014,第3期

机译：一项不同剂量的度他雄胺与安慰剂和非那雄胺在雄激素性脱发男性患者中的疗效和安全性的随机，活性和安慰剂对照研究
4. Development of a Portable Drug Delivery System Using Iontophoresis for Alopecia Treatment [C] . Qun Wei, Dae Guen Hwang, Zia Mohy Ud Din, International Conference on Mechanical and Aerospace Engineering . 2012

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5. Adult Male Sexual Offender Treatment: The Relationship of Schemas, Working Alliance, and Treatment Outcome. [D] . Norbury-Jaranson, Jill C. 2016

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6. Finasteride Counseling for Male Androgenetic Alopecia Should Reflect Updated Findings on Prostate Cancer Risk [O] . Christine C. Akoh, Kumar Sukhdeo 2020

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机译：非那雄胺在治疗雄激素性脱发（男性型脱发）中的用途

FINASTERIDE AS A TREATMENT FOR MALE ANDROGENETIC ALOPECIA

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