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首页> 外文期刊>Journal of the European Academy of Dermatology and Venereology: JEADV >A randomized, double‐blind controlled study of the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil vs. 3% minoxidil solution in the treatment of male androgenetic alopecia
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A randomized, double‐blind controlled study of the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil vs. 3% minoxidil solution in the treatment of male androgenetic alopecia

机译：随机，双盲对照研究0.25％的小甾醇与3％米诺伊唑酯与3％明氧基硅溶液混合的局部溶液的疗效和安全性在治疗雄性和生殖血症

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Abstract Background The synergism of combined use between oral finasteride and topical minoxidil has been established in treating androgenetic alopecia among men. However, the concern regarding adverse effects of finasteride use has been rising. Objective To compare the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil vs. 3% minoxidil solution in men with androgenetic alopecia. Methods Forty men aged 18–60?years with androgenetic alopecia were randomized to 24?weeks of treatment with a finasteride/minoxidil or minoxidil solution twice daily. Primary efficacy endpoint was the change from baseline in hair density and hair diameter at week 24. Secondary endpoints included global photographic assessment by treatment‐blinded investigators and subjects. Changes in plasma dihydrotestosterone levels and adverse events were recorded. Results At week 24, the combined solution of finasteride and minoxidil was significantly superior to minoxidil alone in improvements of hair density, hair diameter and global photographic assessment (all P? ? 0.05). About 90% of patients treated with the combined solution experienced moderate to marked improvement. The combined solution also had minimal effect on plasma dihydrotestosterone levels, approximately 5% reduction. There were also no systemic adverse events reported by patients in both groups. Conclusion Treatment with topical solution of 0.25% finasteride admixed with 3% minoxidil was significantly superior to 3% minoxidil solution for promoting hair growth in male androgenetic alopecia, and well tolerated.
机译：摘要背景，在治疗男性血小霉病患者中，在治疗嗜血症和局部明辛硅之间的组合使用协同作用。然而，关于结束用途使用的不利影响的关注一直在上升。目的比较局部溶液与3％Minoxidil与3％Minoxidil溶液混合的局部溶液的疗效和安全性与Anderogency Alopecia中的男性。方法28-60岁的40万岁的男性与雄激素脱发的年龄为24周，每天两次用过滤器/明肟或明辛硅溶液治疗。初级疗效终点是在第24周的毛发密度和毛发直径的基线变化。次要终点包括治疗盲化调查人员和受试者的全球摄影评估。记录了血浆二氢酮水平和不良事件的变化。结果在第24周，结母酸钠和明肟的组合溶液仅优于Minoxidil，仅在毛发密度，毛发直径和全球摄影评估的改善中（所有p≤0.05）。大约90％的患者患有合并溶液的患者经历了中度至明显的改善。合并的溶液对血浆二氢酮水平的影响最小，减少约5％。两组患者也没有报告的全身不良事件。结论局部溶液对3％明氧基硅氧化物混合的局部溶液的处理显着优于3％少氧化硅溶液，用于促进雄性和血管生殖症中的毛发生生长，耐受性良好。

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