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Nonmedicinal Interventions in Nonalcoholic Fatty Liver Disease

机译：非酒精性脂肪肝疾病的非医学干预

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Unhealthy diet and lack of physical exercise are responsible for fat accumulation in the liver, which may lead to liver disease. Histologically, the severity of the disease has two stages nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). NAFLD is defined by the presence of steatosis with no evidence of cellular injury such as hepatocyte ballooning. NASH is a distinct entity from NAFLD, and is characterized by the presence of inflammation with hepatocytes damage, with or without fibrosis. While several therapeutic strategies have been proposed to improve this condition, the present review aims to discuss nonmedicinal interventions used to reduce liver involvement or to prevent the disease altogether. The authors investigated dietary patterns and vitamin deficiencies associated with NAFLD, and their role in enhancing disease severity. Additionally, they reviewed the role of exercise and the use of interventions, such as as intragastric balloon and bariatric surgery, for improving disease progression. The authors propose monitoring disease progression or repair by following changes in cytoadipokine levels.
机译：不健康的饮食和缺乏运动是造成肝脏中脂肪堆积的原因，这可能导致肝脏疾病。从组织学上讲，该疾病的严重程度分为两个阶段：非酒精性脂肪肝疾病（NAFLD）和非酒精性脂肪性肝炎（NASH）。 NAFLD的定义是存在脂肪变性，没有细胞损伤（如肝细胞膨胀）的迹象。 NASH是与NAFLD截然不同的实体，其特征是存在或不存在纤维化的肝细胞损伤炎症。虽然已经提出了几种改善这种状况的治疗策略，但本综述旨在讨论用于减少肝脏受累或完全预防该疾病的非医学干预措施。作者研究了与NAFLD相关的饮食模式和维生素缺乏症，以及它们在增强疾病严重程度中的作用。此外，他们回顾了运动的作用以及干预措施（例如胃内球囊和减肥手术）对改善疾病进展的作用。作者建议通过跟踪细胞脂肪因子水平的变化来监测疾病的进展或修复。

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