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首页> 外文期刊>ISRN Veterinary Science >Metabolic and Hormonal Alterations with Diacylglycerol and Low Glycemic Index Starch during Canine Weight Loss
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Metabolic and Hormonal Alterations with Diacylglycerol and Low Glycemic Index Starch during Canine Weight Loss

机译：犬体重减轻期间二酰基甘油和低血糖指数淀粉的代谢和激素变化

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Obesity increases insulin resistance and disregulation of glucose homeostasis. This study investigated low glycemic index starch (LGIS)/diacylglycerol (DAG) diet on plasma insulin and circulating incretin hormones during canine weight loss. Obese Beagle dogs were fed one of four starch/oil combination diets (LGIS/DAG; LGIS/triacylglycerol (TAG); high glycemic index starch (HGIS)/DAG; and HGIS/TAG) for 9 weeks during the weight loss period. At weeks 1 and 8, fasting plasma insulin, glucose, nonesterified fatty acid (NEFA), glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) were determined. Weight loss did not affect fasting insulin, glucose, and NEFA, but fasting GIP increased and GLP-1 decreased. LGIS affected postprandial insulin at both times and glucose was similar to insulin, except 60?min postprandially with DAG at week 8. NEFA lowering was less with the LGIS diets initially but not thereafter. At 60?min postprandially on week 8, GIP was significantly elevated by DAG, while GLP-1 was increased only with the HD diet. LGIS suppressed insulin and glucose responses up to 180?min postprandially at both sample times. DAG increased incretin hormones as did the DAG/HGIS combination but only at week 8. This latter finding appeared to be related to the glucose response but not to insulin at 60?min.
机译：肥胖会增加胰岛素抵抗和葡萄糖稳态的失调。这项研究调查了犬体重减轻过程中低血糖指数淀粉（LGIS）/二甘油甘油（DAG）饮食对血浆胰岛素和循环肠降血糖素激素的影响。在减肥期间，给肥胖的Beagle犬喂食四种淀粉/油混合饮食之一（LGIS / DAG; LGIS /三酰甘油（TAG）;高血糖指数淀粉（HGIS）/ DAG; HGIS / TAG）。在第1周和第8周，确定空腹血浆胰岛素，葡萄糖，非酯化脂肪酸（NEFA），葡萄糖依赖性促胰岛素多肽（GIP）和胰高血糖素样肽1（GLP-1）。体重减轻并未影响空腹胰岛素，葡萄糖和NEFA，但空腹GIP增加而GLP-1减少。 LGIS在两个时间都影响餐后胰岛素，葡萄糖与胰岛素相似，除了在餐后第8周用DAG餐后60分钟外，最初使用LGIS饮食的NEFA降低较少，但此后没有。餐后第8周的60分钟时，DAG显着提高了GIP，而仅HD饮食增加了GLP-1。在两个采样时间，LGIS均能在餐后180分钟内抑制胰岛素和葡萄糖反应。 DAG与DAG / HGIS联合使用时增加了肠降血糖素激素，但仅在第8周时才出现。这一发现似乎与葡萄糖反应有关，但与60分钟时的胰岛素无关。

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