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首页> 外文期刊>Iranian Journal of Neurology >Molecular changes in obese and depressive patients are similar to neurodegenerative disorders
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Molecular changes in obese and depressive patients are similar to neurodegenerative disorders

机译：肥胖和抑郁症患者的分子变化类似于神经退行性疾病

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Background: Neurodegenerative disorders (NDs) are categorized as multifactorial conditions with different molecular and environmental causes. Disturbance of important signaling pathways, such as energy metabolism and inflammation induced by environmental agents, is involved in the pathophysiology of NDs. It has been proposed that changes in the lifestyle and nutrition (metabolism) during mid-life could trigger and accumulate cellular and molecular damages resulting in NDs during aging.Methods: In order to test the hypothesis, we investigated the expression level of two energy metabolism-related [forkhead box O1 (FOXO1) and forkhead box O3 (FOXO3A)] and two pro-inflammatory cytokines [interleukin 1β (IL-1β) and IL-6] genes, using quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR). Furthermore, changes in the ionic concentration of three essential heavy metals [iron (Fe), copper (Cu), and zinc (Zn)] by atomic absorption spectroscopy in patients with NDs, depression, obesity, and diabetes type II, were evaluated and compared with the results of normal individuals.Results: More than half of the participants in obesity, depression, and ND groups had significant up-regulation of FOXO1 and FOXO3A, down-regulation of IL-1β and IL-6, and higher levels of Fe and Cu in their blood. This pattern of gene expression was not repeated in diabetic patients.Conclusion: It could be concluded that individuals affected with different levels of obesity and depression have increased risk of developing NDs later in life, probably through changes in energy metabolism, inflammatory pathways, and ionic concentrations.
机译：背景：神经退行性疾病（NDs）被归类为多因素疾病，其分子和环境原因不同。 ND的病理生理涉及重要信号通路的干扰，例如能量代谢和环境因子诱导的炎症。有人提出中年人的生活方式和营养（新陈代谢）的变化可以触发并积累细胞和分子损伤，从而导致衰老过程中的ND。方法：为了检验这一假设，我们研究了两种能量代谢的表达水平相关的[叉头盒O1（FOXO1）和叉头盒O3（FOXO3A）]和两个促炎性细胞因子[白介素1β（IL-1β）和IL-6]基因，使用定量逆转录酶聚合酶链反应（qRT-PCR） ）。此外，通过原子吸收光谱法评估了ND，抑郁症，肥胖症和II型糖尿病患者中三种必需重金属[铁（Fe），铜（Cu）和锌（Zn）]的离子浓度变化，并进行了评估，结果：肥胖，抑郁和ND组中超过一半的参与者FOXO1和FOXO3A显着上调，IL-1β和IL-6上调，以及更高水平的肥胖。血液中的铁和铜。结论：可以得出结论，患有不同程度的肥胖和抑郁症的人在生命后期可能会通过能量代谢，炎症途径和离子途径的改变而增加罹患ND的风险。浓度。

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