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首页> 外文期刊>Iranian Journal of Neurology >Human T-lymphotropic virus type I and breastfeeding; systematic review and meta-analysis of the literature
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Human T-lymphotropic virus type I and breastfeeding; systematic review and meta-analysis of the literature

机译：人I型T淋巴细胞病毒和母乳喂养;对文献进行系统的回顾和荟萃分析

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Background: The human T-cell lymphotropic virus type-I (HTLV-I) is the first identified pathogenic human retrovirus. Breastfeeding has been reported to be the predominant route of vertical transmission of HTLV-I. The objective of this systematic review was to pool and evaluate the data on the transmission of HTLV-I with different infant-feeding practices on children born to HTLV-I-positive mothers. We conducted a systematic review of comparison of HTLV-I transmission risk to breastfed and bottle-fed babies. Methods: We searched the following databases: MEDLINE, SID, Magiran, and Cochrane Library. The search strategy was limited to articles in English. Initial screening identified 254 citations; of these, 96 potentially relevant articles were identified. After reviewing the 96 full-text articles in detail, 7 reports met the inclusion criteria for this review. Results: Pooled odds ratio (OR) and risk difference (RD) of HTLV-I transmission in the breastfed group compared to the bottle-fed infants were [OR = 3.48, 95% confidence interval (CI): 1.58-7.64, P = 0.0020, Cochran’s Q = 27.7, P = 0.0010, and I2 = 67.5%] and (RD = 17.1%, 95% CI: 7.5%-26.7%, P 0.0001, Cochran’s Q = 106, P 0.0001, and I2 = 91.5%). So, we have evidence to support that exclusive breast feeding more than 6 months in comparison to bottle feeding highly increases transmission rate of HTLV-I infection. We have also enough evidence to support that exclusive breast feeding up to 6 months compared to bottle feeding does not increase transmission rate of HTLV-I infection (pooled OR = 0.912, CI: 0.45-1.80; OR: 3.83, CI: 1.80-8.10, respectively). Conclusion: The current meta-analysis showed that short period (less than 6 months) of breastfeeding did not increase risk of HTLV-I infection transmission from mother to child among breastfeeders and more than 6 months of breastfeeding significantly increased the risk of HTLV-I infection. However, our meta-analysis shows that refraining from breastfeeding can decrease the risk of vertical HTLV-I transmission.
机译：背景：人类T细胞淋巴病毒I型（HTLV-1）是第一种被鉴定为致病性人类逆转录病毒。据报道母乳喂养是HTLV-1垂直传播的主要途径。这项系统评价的目的是汇总和评估关于HTLV-1阳性母亲所生子女采用不同婴儿喂养方式传播HTLV-1的数据。我们对母乳喂养和人工喂养的婴儿的HTLV-1传播风险进行了比较的系统评价。方法：我们搜索了以下数据库：MEDLINE，SID，Magiran和Cochrane库。搜索策略仅限于英文文章。初步筛选确定了254条引用文献;其中，确定了96篇可能相关的文章。在详细审查了96篇全文文章之后，有7份报告符合该审查的纳入标准。结果：与奶瓶喂养婴儿相比，母乳喂养组HTLV-1传播的合并比值比（OR）和风险差异（RD）为[OR = 3.48，95％置信区间（CI）：1.58-7.64，P = 0.0020，Cochran's Q = 27.7，P = 0.0010，I2 = 67.5％]和​​（RD = 17.1％，95％CI：7.5％-26.7％，P <0.0001，Cochran's Q = 106，P <0.0001，I2 = 91.5％）。因此，我们有证据支持与母乳喂养相比，纯母乳喂养超过6个月可以大大提高HTLV-1感染的传播率。我们也有足够的证据支持与母乳喂养相比，仅母乳喂养长达6个月不会增加HTLV-1感染的传播率（合并OR = 0.912，CI：0.45-1.80; OR：3.83，CI：1.80-8.10 ， 分别）。结论：当前的荟萃分析显示，母乳喂养的短期（少于6个月）不会增加HTLV-I感染在母乳喂养中由母婴传播的风险，并且母乳喂养超过6个月会显着增加HTLV-I的风险感染。但是，我们的荟萃分析表明，避免母乳喂养可降低HTLV-1垂直传播的风险。

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