Colchicine resistant FMF is not always true resistance

Tawhida Y. Abdel Ghaffar; Solaf M. Elsayed

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Colchicine resistant FMF is not always true resistance

机译：耐秋水仙碱的FMF并不总是真正的耐药性

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Crohn’s disease and familial Mediterranean fever are both inflammatory diseases characterized by similar clinical manifestations. The concurrence of the two diseases may pose a challenge to diagnosis and treatment. In this report, we present a child with familial Mediterranean fever and undiagnosed Crohn’s disease which made him apparently resistant to colchicine therapy. Symptoms of Crohn’s disease were masked by the resistant fever of FMF. Amelioration of symptoms of both diseases was achieved when treatment of both diseases were gradually introduced. Searching of IBD in children with colchicines resistant FMF is mandatory, as both diseases have similar symptoms and responsible genes may modify one another.

机译：克罗恩病和家族性地中海热都是以相似的临床表现为特征的炎症性疾病。两种疾病的并存可能对诊断和治疗构成挑战。在这份报告中，我们介绍了一个患有家族性地中海热和克罗恩氏病（未确诊）的孩子，这使他显然对秋水仙碱疗法有抵抗力。 FMF抵抗热掩盖了克罗恩病的症状。当逐渐引入两种疾病的治疗时，两种疾病的症状得到改善。必须对具有秋水仙碱抗性FMF的儿童进行IBD搜索，因为这两种疾病都有相似的症状，并且负责任的基因可能会相互修饰。

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《Egyptian Journal of Medical Human Genetics》 |2011年第1期|共3页
作者
Tawhida Y. Abdel Ghaffar; Solaf M. Elsayed;
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1. The familial Mediterranean fever (FMF) 50 score: does it work in a controlled clinical trial? Re-analysis of the trial of rilonacept for patients with colchicine resistant or intolerant FMF [J] . P Hashkes, B Huang Pediatric rheumatology online journal . 2015,第S1期

机译：家族性地中海热（FMF）50分数：在对照临床试验中有效吗？对秋水仙碱耐药或不耐受的FMF患者的rilonacept试验的重新分析
2. Successful treatment with anti-tumor necrosis factor (anti-TNF)-alpha of proteinuria in a patient with familial mediterranean fever (FMF) resistant to colchicine: anti-TNF drugs and FMF. [J] . S Erten, S F Erten, A Altunoglu Rheumatology international. . 2012,第4期

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6. The familial Mediterranean fever (FMF) 50 score: does it work in a controlled clinical trial? Re-analysis of the trial of rilonacept for patients with colchicine resistant or intolerant FMF [O] . P Hashkes, B Huang 2015

机译：家族性地中海热（FMF）50分：在对照临床试验中有效吗？对秋水仙碱耐药或不耐受的FMF患者的rilonacept试验的重新分析
7. Colchicine resistant FMF is not always true resistance [O] . Ghaffar Tawhida Y. Abdel, Elsayed Solaf M. 2011

机译：耐秋水仙碱的FMF并不总是真正的耐药性

Colchicine resistant FMF is not always true resistance

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