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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Congenital malformations prevalent among Egyptian children and associated risk factors
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Congenital malformations prevalent among Egyptian children and associated risk factors

机译：埃及儿童中普遍存在先天畸形及其相关的危险因素

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According to the World Health Organization the term congenital anomaly includes any morphological, functional, biochemical or molecular defects that may develop in the embryo and fetus from conception until birth, present at birth, whether detected at that time or not. Based on World Health Organization report, about 3 million fetuses and infants are born each year with major malformations. Several large population based studies place the incidence of major malformations at about 2–3% of all live births. In this study we tried to assess the frequency and nature of congenital malformations (CMs) among Egyptian infants and children as well as the associated maternal, paternal and neonatal risk factors. Patients (13,543) having CMs were detected among 660,280 child aged 0–18years attending the Pediatric Hospital Ain Shams University during the period of the study (1995–2009), constituting 20/1000. Males were more affected than females (1.8:1). According to ICD-10 classification of congenital malformations the commonest system involved were, nervous system, followed by chromosomal abnormalities, genital organs, urinary system, musculoskeletal, circulatory system, eye, ear, face, and neck, other congenital anomalies, digestive system, cleft lip and palate, and respiratory anomalies. Among the maternal risk factors detected were multiparity, age of the mother at conception, maternal illness, exposure to pollutants, and intake of the drugs in first months. Consanguineous marriage was detected in 45.8% of patients. Surveys of CMs must be done in every country to provide prevalence, pattern of occurrence, nature, identify causes, and associated risk factors to prevent or reduce the occurrence of CMs.
机译：根据世界卫生组织的说法，先天性异常一词包括从受孕到出生直至出生时在胚胎和胎儿中可能出现的任何形态，功能，生化或分子缺陷，无论当时是否发现。根据世界卫生组织的报告，每年大约有300万胎儿和婴儿出生，患有严重的畸形。几项基于人口的大型研究表明，主要畸形的发生率约占所有活产婴儿的2-3％。在这项研究中，我们试图评估埃及婴儿和儿童中先天性畸形（CM）的频率和性质，以及相关的母亲，父亲和新生儿的危险因素。在研究期间（1995年至2009年），在Ain Shams大学儿科医院的660,280名0-18岁儿童中检测到了CM患者（13,543名），占20/1000。男性比女性受影响更大（1.8：1）。根据ICD-10对先天性畸形的分类，最常见的系统是神经系统，其次是染色体异常，生殖器官，泌尿系统，肌肉骨骼，循环系统，眼，耳，脸和脖子，其他先天性异常，消化系统，唇and裂和呼吸异常。在检测到的孕产妇危险因素中，包括多胎性，受孕母亲的年龄，孕产妇疾病，接触污染物以及在头几个月服用药物。在45.8％的患者中发现近亲通婚。必须在每个国家进行CM的调查，以提供患病率，发生方式，性质，查明原因以及相关的危险因素，以防止或减少CM的发生。

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