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Metadherin mRNA expression in hepatocellular carcinoma

机译:肝细胞癌组织中Metadherin mRNA的表达。

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Background Metadherin (MTDH) has been known as an essential oncogene in carcinogenesis and tumor spread in several malignancies, via its effect on pathways of signal transduction. Objective We aimed to evaluate the role of serum MTDH mRNA expression in the diagnosis of hepatocellular carcinoma (HCC) and to compare its expression levels with serum levels of Alpha-fetoprotein (AFP). Subjects & methods A total of 150 subjects (90 HCC patients & 60 healthy volunteers) were enrolled in the current study. Serum MTDH mRNA relative expression was analyzed by Real Time PCR technique. Results There was a significant statistical increase of serum MTDH mRNA expression in HCC group when compared to controls (P?
机译:背景Metadherin(MTDH)通过其对信号传导途径的影响,已被认为是致癌和多种恶性肿瘤扩散中必不可少的致癌基因。目的探讨血清MTDH mRNA表达在肝细胞癌(HCC)诊断中的作用,并与血清甲胎蛋白(AFP)水平进行比较。受试者与方法本研究共纳入150名受试者(90例HCC患者和60名健康志愿者)。通过实时PCR技术分析血清MTDH mRNA的相对表达。结果与对照组相比,HCC组血清MTDH mRNA的表达有统计学意义的增加(P <0.05)。 MTDH mRNA表达与HCC患者的临床病理数据,晚期肿瘤分期和较弱的组织学分化密切相关(p <0.05)。 HCC组MTDH mRNA表达与血清AFP水平呈正相关(r≥0.445),P值≥0.05。用ROC曲线验证MTDH mRNA表达的准确性,并与血清AFP的准确性进行HCC诊断。 MTDH mRNA表达比AFP具有更高的准确性(92%),敏感性(91%)和特异性(93%)。结论肝癌患者血清MTDH mRNA表达上调; MTDH可以被认为是HCC诊断的非侵入性生物标志物,因为它具有更高的准确性,因此可以代替血清AFP进行HCC诊断。

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