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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India
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An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India

机译：印度北部apo-A4基因多态性（Thr347Ser和Gln360His）与冠状动脉疾病之间的关联

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Background Coronary artery disease (CAD) is emerging as a major health problem in India. It is predicted that by 2020, India will be at the verge of CAD epidemic. A low level of high-density lipoproteins (HDL) is prevalent in Asian Indians and is the major lipid risk factor for CAD. HDL contains Apo A, E, C and antioxidant enzymes. The genetic variants of these proteins appear to influence the occurrence and frequency of CAD. In this context APO A4 have drawn much attention. The polymorphisms at Thr347Ser and Gln360His of the apo A4 gene are under investigation in different parts of the world in relation to dyslipidemias, diabetes and CAD. Since data are conflicting and no conclusive data is available from India. Objective We aimed at studying the relationship between apoA4 gene polymorphisms (Thr347Ser and Gln360His) and coronary artery disease in northern Indian participants. Method We recruited 200 control (Group-I) and 200 patients (Group-II) and used PCR-RFLP to study the gene polymorphisms. Enzymatic Kits were used to estimate the lipids and lipoproteins. Result We observed not any significant association for ApoA4 Thr347Ser polymorphism as well as lipid profile [total cholesterol (TC), triglyceride (TG), HDL, low-density lipoproteins (LDL) and HDL/LDL] levels among AA, AT and TT Individuals in controls and patients. However, after adjusting for age and sex, among control AA genotype had significantly lower levels of oxidised LDL (OXLDL) as compared to AT genotype and in patients, levels of OXLDL in AT genotype was lower than with AA genotype and for ApoA4 Gln360His polymorphism, after adjusting for age and sex, and no significant difference was observed in TC, TG, HDL, LDL and HDL/LDL, OXLDL and LDL / OXLDL levels among 1–1, and 1–2. Individuals in controls and patients. Conclusion To accomplish, this preliminary study brought the information on the ApoA4 polymorphism in the Asian Indians residing in Delhi and adjacent areas. The minor alleles of the Ser347 and His360 showed significant association with lipid risk factors like high levels of OXLDL, TC, and low HDL levels. However neither of these polymorphisms showed an association with CAD.
机译：背景技术在印度，冠状动脉疾病（CAD）逐渐成为主要的健康问题。预计到2020年，印度将处于CAD流行的边缘。低水平的高密度脂蛋白（HDL）在亚洲印第安人中普遍存在，并且是CAD的主要脂质危险因素。 HDL包含Apo A，E，C和抗氧化酶。这些蛋白质的遗传变异似乎影响CAD的发生和频率。在这种情况下，APO A4引起了很多关注。关于血脂异常，糖尿病和CAD，世界各地正在研究apo A4基因Thr347Ser和Gln360His的多态性。由于数据存在冲突，印度没有确切的数据可用。目的我们旨在研究印度北部参与者apoA4基因多态性（Thr347Ser和Gln360His）与冠状动脉疾病之间的关系。方法我们招募了200名对照组（I组）和200名患者（II组），并使用PCR-RFLP研究了基因多态性。酶试剂盒用于估计脂质和脂蛋白。结果我们发现AA，AT和TT患者中ApoA4 Thr347Ser多态性与脂质谱[总胆固醇（TC），甘油三酸酯（TG），HDL，低密度脂蛋白（LDL）和HDL / LDL]水平没有显着相关性在对照组和患者中。但是，在调整了年龄和性别之后，与AAT基因型相比，对照AA基因型的氧化LDL（OXLDL）水平显着降低，并且患者中，AT基因型的OXLDL水平低于AA基因型和ApoA4 Gln360His多态性，在调整了年龄和性别之后，TC，TG，HDL，LDL和HDL / LDL，OLXDL和LDL / OLXDL的水平在1-1和1-2之间没有显着差异。对照组和患者中的个体。结论为了完成这项初步研究，该研究为居住在德里及其邻近地区的亚洲印第安人提供了有关ApoA4多态性的信息。 Ser347和His360的次要等位基因与脂质危险因素（如OXLDL，TC含量高和HDL含量低）显着相关。但是，这些多态性均未显示与CAD相关。

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