• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Renalase gene polymorphisms (rs2576178 and rs10887800) in Egyptian hypertensive end stage renal disease patients
【24h】

Renalase gene polymorphisms (rs2576178 and rs10887800) in Egyptian hypertensive end stage renal disease patients

机译：埃及高血压晚期肾病患者肾病酶基因多态性（rs2576178和rs10887800）

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background The highly polymorphic gene encoding human renalase (RNLS) is a 311,000?bp gene located on chromosome 10. Aim This study aimed at studying the possible association of the two RNLS gene polymorphisms rs2576178 and rs10887800 with chronic kidney disease in general or specifically with hypertensive nephropathy in Egyptian end stage renal disease (ESRD) patients on maintenance hemodialysis. Subjects and method This case control study was conducted on two hundred and eighty one individuals, divided equally into two groups; an end stage renal disease patients on maintenance hemodialysis with/without hypertension and healthy matching individuals as a control group. Full clinical examination, Biochemical analysis and Molecular genetic testing were performed to detect single nucleotide polymorphism using restriction fraction length polymorphism (RFLP) for RNLS rs2576178 and rs1088780. Results The results of this study demonstrated that the risk of developing ESRD was increased among carriers of AA genotype for the rs10887800 (3.05 times) p?=?0.001, OR?=?3.05, CI95% (1.558–5.971) and GG genotype for the rs2576178 p?=?0.047, OR?=?1.949, CI95% (1.028–3.694). Conclusion Our study revealed that the risk of developing end stage renal diseases was increased among carriers of AA genotype for the rs10887800 polymorphism and GG genotype for the rs2576178 polymorphism.
机译：背景技术高度编码的人类肾病酶（RNLS）基因是位于10号染色体上的311,000bp基因。目的本研究旨在研究两种RNLS基因多态性rs2576178和rs10887800与慢性肾脏疾病的总体或特异性与高血压的可能关系。肾病埃及终末期肾病（ESRD）患者接受维持性血液透析。对象和方法本病例对照研究是对281个个体进行的，将其平均分为两组。接受/不伴高血压维持性血液透析的终末期肾病患者和健康个体作为对照组。进行了完整的临床检查，生化分析和分子遗传测试，以使用RNLS rs2576178和rs1088780的限制性片段长度多态性（RFLP）检测单核苷酸多态性。结果这项研究的结果表明，对于rs10887800（3.05倍），p？=？0.001，OR？=？3.05，CI95％（1.558-5.971）和GG基因型，AA基因型携带者，罹患ESRD的风险增加。 rs2576178 p？=？0.047，或？== 1.949，CI95％（1.028–3.694）。结论我们的研究表明，在rs10887800多态性的AA基因型携带者和rs2576178多态性的GG基因型携带者中，罹患终末期肾脏疾病的风险增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号