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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >New insights into smudge cell percentage in chronic lymphocytic Leukemia: A novel prognostic indicator of disease burden
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New insights into smudge cell percentage in chronic lymphocytic Leukemia: A novel prognostic indicator of disease burden

机译：慢性淋巴细胞白血病中污点细胞百分比的新见解：疾病负担的新预后指标

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Background Percentage of smudge cells in CLL patients has recently been reported as a novel prognostic factor. Objectives To investigate the impact of smudge cells percentage on the clinicolaboratory data of CLL patients and to evaluate the relationship between it and other prognostic factors in CLL. Methods Ninety adults with CLL were enrolled. Smudge cells percentage was calculated by microscopic evaluation of blood smears. Testing of CD38 expression was done by immunophenotyping and detection of ATM, P53 deletions and trisomy 12 were performed using fluorescent in situ hybridization (FISH) Results Lower smear cells percentage (<30%) was significantly correlated with age, lymphadenopathy, organomegaly and advanced staging. It was also associated with high TLC, low hemoglobin and platelets count and high absolute and atypical lymphocytic count. Correlation studies with other prognostic factors revealed an association between low smear cells percentage and CD38 expression, short LDT, P53 and ATM deletions. Logistic regression analysis was also done to provide complementary prognostic information identifying the significant independent factors that predict low smear cell percentage. Conclusion low percentage of smudge cells (<30%) could be considered as an adverse prognostic predictor being associated with high risk markers in CLL.
机译：背景技术最近有报道称CLL患者中的污点细胞百分比是一种新的预后因素。目的探讨污染细胞百分比对CLL患者临床实验室数据的影响，并评估其与CLL其他预后因素之间的关系。方法收集了90名CLL成人。通过对血液涂片的显微镜评估来计算污点细胞百分比。通过免疫表型检测CD38表达，并使用荧光原位杂交（FISH）检测ATM，P53缺失和三体性12结果结果较低的涂片细胞百分比（<30％）与年龄，淋巴结病，器官肿大和晚期分期显着相关。它还与高TLC，低血红蛋白和血小板计数以及高绝对和非典型淋巴细胞计数相关。与其他预后因素的相关性研究表明，涂片细胞百分比低与CD38表达，LDT短，P53和ATM缺失短相关。还进行了逻辑回归分析，以提供补充的预后信息，从而确定可预测低涂片细胞百分比的重要独立因素。结论低百分比的污点细胞（<30％）可被视为与CLL中高风险标志物相关的不良预后指标。

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