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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Prevalence of glucose-6-phosphate dehydrogenase deficiency in India: An updated meta-analysis
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Prevalence of glucose-6-phosphate dehydrogenase deficiency in India: An updated meta-analysis

机译：印度6-磷酸葡萄糖脱氢酶缺乏症患病率：最新荟萃分析

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Background Glucose-6-phosphate dehydrogenase (G6PD) is a house keeping enzyme which catalyzes the first step in the hexose monophosphate pathway of glucose metabolism. G6PD deficiency is the commonest hemolytic X-linked genetic disease, which affects approximately 400 million people worldwide. The prevalence rate of G6PD deficiency varies worldwide with a higher prevalence in malarial endemic population. In India several studies were published and reported with varying incidences of this disease in different populations. Objective The aim of the present study was to assess the overall frequency of G6PD deficiency in the Indian population using meta-analysis. Methods PubMed, Science Direct, Google Scholar and Springer Link databases were searched for studies that investigated G6PD deficiency in Indian population. If any author studied different sub-populations we treated the study as an independent study. Results A total of 72 studies with a total sample size of 38,565 and 2,623 G6PD deficient subjects were included in the present meta-analysis. Meta-analysis was performed in both fixed and random effect models. Meta-analysis with random model showed an overall prevalence proportion as 0.085 (95% CI = 0.070–0.103; p = 0.000; tau = 0.826; I 2 = 0.486; Cochran Q = 0.999). Conclusion In conclusion the present meta-analysis confirms the overall magnitude of the frequency of G6PD deficiency (8.5%) in the Indian population.
机译：背景技术6-磷酸葡萄糖脱氢酶（G6PD）是一种管家酶，可催化葡萄糖代谢己糖单磷酸途径中的第一步。 G6PD缺乏症是最常见的溶血性X连锁遗传病，影响全球约4亿人。 G6PD缺乏症的患病率在全世界范围内有所不同，疟疾流行人群的患病率更高。在印度，已发表和报道了几项研究，报告了该疾病在不同人群中的发病率不同。目的本研究旨在通过荟萃分析评估印度人群中G6PD缺乏症的总体发生率。方法搜索PubMed，Science Direct，Google Scholar和Springer Link数据库，以研究印度人口中G6PD缺乏症的研究。如果有任何作者研究了不同的亚群，我们会将其视为独立研究。结果本荟萃分析共纳入72项研究，总样本量为38,565和2,623名G6PD缺陷患者。在固定和随机效应模型中均进行了荟萃分析。随机模型的荟萃分析显示总体患病率为0.085（95％CI = 0.070-0.103; p = 0.000; tau = 0.826; I 2 = 0.486; Cochran Q = 0.999）。结论总之，本荟萃分析证实了印度人群中G6PD缺乏症的总发生频率（8.5％）。

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