• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Iranian Journal of Reproductive Medicine >SAFETY AND EFFICACY OF MISOPROSTOL IN INDUCTION OF LABOUR IN PRELABOUR RUPTURE OF FETAL MEMBRANE IN NIGERIAN WOMEN: A MULTICENTER STUDY
【24h】

SAFETY AND EFFICACY OF MISOPROSTOL IN INDUCTION OF LABOUR IN PRELABOUR RUPTURE OF FETAL MEMBRANE IN NIGERIAN WOMEN: A MULTICENTER STUDY

机译：尼泊尔前体胎膜破裂中米索前列醇引产的安全性和有效性：多中心研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Misoprostol, a prostaglandin E1 analogue compared to prostaglandin E2, has the advantage of being inexpensive and stable at room temperature, with its proven efficacy and safety. However studies on the effect of pH on the efficacy of misoprostol have yielded conflicting results. Thus its use in the induction of labour in patients with premature rupture of membrane requires further investigation.Objective: To evaluate the safety and efficacy of misoprostol in induction of labour in Nigerian women with prelabour rupture of membrane after 34 weeks of gestation.Materials and Methods: Three hundred and forty six Nigerian women with prelabour rupture of membrane who consented to participate in the trial were randomised into two arms of misoprostol and oxytocin. Labour was managed with WHO partograph. The primary outcome was the caesarean section rate and induction vaginal delivery interval. Results: The mean induction to vaginal delivery interval was significantly shorter in the misoprostol arm (504 mins) compared to 627 mins in the oxytocin arm (t=3.97; p=0.005). The caesarean section rate of 18.1% among the misoprostol arm was also significantly lower than the 41.4% recorded in the oxytocin arm (p=0.002). Among patients with Bishop score greater than 6 there were no statistically significant differences between the two groups in the outcomes measured. Conclusion: Misoprostol is not only effective but also safe when compared with titrated oxytocin in Nigerian parturients with prelabour rupture of membrane after 34 weeks.
机译：背景：米索前列醇（一种与前列腺素E2相比的前列腺素E1类似物）具有价格低廉且在室温下稳定的优势，并具有公认的功效和安全性。但是，有关pH对米索前列醇功效的影响的研究得出了相互矛盾的结果。因此，其在胎膜早破患者引产中的应用有待进一步研究。目的：评价米索前列醇在尼日利亚妊娠34周后胎膜早破妇女引产中的安全性和有效性。 ：将同意参加试验的346名尼日利亚有分娩前胎膜早破的妇女随机分为米索前列醇和催产素两支。人工由世卫组织分区仪管理。主要结局是剖腹产率和诱导阴道分娩间隔。结果：米索前列醇组对阴道分娩间隔的平均诱导时间（504分钟）明显短于催产素组的627分钟（t = 3.97; p = 0.005）。米索前列醇组的剖腹产率为18.1％，也明显低于催产素组的41.4％（p = 0.002）。在Bishop评分大于6的患者中，两组之间在测量结果方面无统计学差异。结论：与滴定的催产素相比，米索前列醇在尼日利亚产前胎膜早破34周的产妇中不仅有效，而且安全。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号