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首页> 外文期刊>Iranian Journal of Reproductive Medicine >STUDY OF ULTRASTRUCTURE AND APOPTOSIS IN THE ENDOMETRIUM OF WOMEN WITH OR WITHOUT ENDOMETRIOSIS
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STUDY OF ULTRASTRUCTURE AND APOPTOSIS IN THE ENDOMETRIUM OF WOMEN WITH OR WITHOUT ENDOMETRIOSIS

机译：有或没有子宫内膜异位的女性子宫内膜超微结构和凋亡的研究

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Background: More than 40% of infertilities are due to endometriosis. Ultrustructural and histochemical study of endometrium will help to clarify the etiology of endometriosis.Objective: The aim of the present study was to investigate the ultrastructure and occurrence of apoptosis in endometrial cells of women with or without endometriosis.Materials and Methods: In the present case-control study, endometrial specimens from 12 women without endometriosis (as control) and 12 women with endometriosis (as case) were examined. Specimens for control group were obtained from the patients that were referred to gynecology hospital for hysterectomy due to various reasons. In case group the endometriosis was diagnosed according to laparoscopy and endometrial samples were taken using pippel biopsy. The specimens from both case and control groups were processed for Transmission Electron Microscopy (TEM), TUNEL reaction technique and morphometric studies.Results: The results show that endometrial epithelium lost its continuity in women with endometriosis and endometrial cells have euchromatic nucleus in comparison to those from non-endometriosis. There were several apoptotic cells in the luminal and glandular endometrial epithelium and stroma from endometrium of control group. However, apoptotic cells were rarely seen in the endometrium from women with endometriosis. The difference in number of apoptotic cells between two groups statically was significant (p0.001).Conclusion: Regarding the ultrastructural characteristics of endometrial epithelial cells and comparison of apoptotic occurrence in control and case groups it is concluded that endometrial cells in endometriosis group have higher potential to survive and possibly implant.
机译：背景：40％以上的不孕症是由于子宫内膜异位症引起的。子宫内膜的组织结构和组织化学研究将有助于阐明子宫内膜异位症的病因。目的：本研究的目的是研究有无子宫内膜异位症的妇女子宫内膜细胞的超微结构和凋亡的发生。材料和方法：对照研究，检查了12例无子宫内膜异位症的妇女（作为对照）和12例子宫内膜异位症（作为病例）的子宫内膜标本。对照组的标本来自因各种原因而被转诊至妇科医院进行子宫切除术的患者。在病例组中，根据腹腔镜检查诊断为子宫内膜异位症，并使用腹腔镜活检术采集子宫内膜样品。对病例和对照组的标本进行了透射电镜（TEM），TUNEL反应技术和形态计量学研究。结果：结果表明，子宫内膜异位症患者的子宫内膜上皮丧失了连续性，子宫内膜细胞与正常人相比具有正常的核来自非子宫内膜异位症。对照组子宫内膜腔和腺内膜上皮及间质中有多个凋亡细胞。但是，子宫内膜异位症妇女的子宫内膜很少见凋亡细胞。两组之间的凋亡细胞数量静态差异显着（p <0.001）。结论：关于子宫内膜上皮细胞的超微结构特征以及对照组和病例组的凋亡发生率的比较，可以得出结论：子宫内膜异位组的子宫内膜细胞具有较高的凋亡率。生存的潜力，并可能植入。

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