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首页> 外文期刊>Iranian Journal of Reproductive Medicine >POST-TREATMENT WITH TELFAIRIA OCCIDENTALIS SEED OIL ATTENUATES ALCOHOL-INDUCED TESTICULAR DAMAGE IN SPRAGUE-DAWLEY RATS
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POST-TREATMENT WITH TELFAIRIA OCCIDENTALIS SEED OIL ATTENUATES ALCOHOL-INDUCED TESTICULAR DAMAGE IN SPRAGUE-DAWLEY RATS

机译：西番莲种子油的后处理可减轻酒精引起的斯普拉格-道利大鼠的损伤。

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Background: Long term alcohol use has been implicated in men with sexual disorders including suppression of testosterone levels as well as testicular morphological changes.Objective: This research investigated the ability of Telfairia occidentalis (T.O.) to attenuate the damaging effects of alcohol on the testicular parameters. Materials and Methods: Thirty male Sprague-Dawley rats, 170-190 grams were divided into 6 groups, A to F and treated with distilled water (DW) for the period of 8 weeks (positive control group A), ethanol for 2 weeks followed with DW for 6 weeks (group B) (negative control), ethanol alone for 2 weeks (group C) while others received ethanol for 2 weeks, followed with 200 (group D), 400 (group E) and 600 mg/kg (group F) of T.O. for 6 weeks.Results: Testicular histological sections showed that ethanol produced marked loss of testicular germ cells after two weeks of administration. T.O (200 mg/kg body weight) was not able to attenuate this microanatomical distortion when compared with control groups, but at 400 mg/kg body weight, T.O reversed the ethanol`s effects with resultant significant increase in sperm count and motility (p0.05), serum testosterone levels (p0.05), and testicular weight (p0.05). However, at 600 mg/kg dosage, there was marked depletion of testicular germ cells with atrophied seminiferous tubules and a decrease in semen parameters and testicular weight.Conclusion: Our result suggests that T.O promotes the regeneration of testicular germ cells and improves semen quality at a certain critical dose. Hence, T.O has a potential of reversing ethanol induced testicular damage.
机译：背景：长期饮酒已涉及性障碍男性，包括抑制睾丸激素水平以及睾丸形态变化。目的：这项研究调查了西洋蓟（Telfairia occidentalis，TO）减弱酒精对睾丸参数的破坏作用的能力。 。材料与方法：将30只雄性Sprague-Dawley大鼠（170-190克）分为6组（从A到F），并用蒸馏水（DW）处理8周（阳性对照组A），然后用乙醇处理2周DW治疗6周（B组）（阴性对照组），仅乙醇治疗2周（C组），而其他人则接受乙醇2周，其次是200（D组），400（E组）和600 mg / kg TO的F组结果：持续6周。结果：睾丸组织切片显示，给药两周后乙醇产生睾丸生殖细胞的明显损失。与对照组相比，TO（200 mg / kg体重）不能减轻这种微解剖学变形，但是在400 mg / kg体重下，TO逆转了乙醇的作用，导致精子数量和运动力显着增加（p <0.05），血清睾丸激素水平（p <0.05）和睾丸重量（p <0.05）。然而，在600 mg / kg剂量下，睾丸生殖细胞明显萎缩，生精管萎缩，精液参数和睾丸重量降低。结论：我们的结果表明TO可以促进睾丸生殖细胞的再生并改善精液质量。一定的临界剂量。因此，T.O具有逆转乙醇诱发的睾丸损伤的潜力。

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