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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Clinical profile of cyanotic congenital heart disease in neonatal intensive care unit at Sohag University Hospital, Upper Egypt
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Clinical profile of cyanotic congenital heart disease in neonatal intensive care unit at Sohag University Hospital, Upper Egypt

机译：上埃及苏哈格大学医院新生儿重症监护室发cyan性先天性心脏病的临床概况

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Background Cyanotic congenital heart disease (CCHD) accounts for 25% of congenital heart defects and has a high morbidity and mortality in neonates. Objective The aim of this work was to study clinical profile and available therapeutic modalities used in the management of CCHD. Subjects and methods This was a prospective study carried out for a period of one year, starting from January 2011, and included 50 neonates admitted to neonatal intensive care unit (NICU) of Sohag University Hospital, Sohag, Upper Egypt. All included patients were subjected to thorough clinical history, full clinical examination, initial and frequent measurement of oxygen saturation by pulse oximetry, blood gas analysis, and echocardiography. Also, therapeutic modalities used in management of CCHD were noted. Results 50 neonates were diagnosed as having CCHD, out of them 39 (78%) were males with male to female ratio 3.55:1. The mean age of presentation was 11.78 ± 9.4 days. CCHD frequency was found to be 9.5% (50/524) in our NICU population. The most common type of CCHD was d-transposition of great arteries (D-TGA) (66%) followed by complex CCHD (12%) and hypoplastic left heart syndrome (HLHS) (12%), whereas the less common type was hypoplastic right ventricle (2%). All cases presented with central cyanosis and needed medical treatment whereas balloon atrial septostomy was performed in 26% of cases. Seventy-four percent of cases were improved and referred to higher centers while 26% were expired during hospital stay. Conclusion CCHD is a leading cause of neonatal morbidity and mortality. CCHD frequency was significant (9.5%) in our study population with D-TGA being the commonest type. Majority of neonates with CCHD showed survival with suitable management. Early diagnosis and referral to pediatric cardiac center for proper management will improve the outcome. Neonatologists and pediatric cardiologists should be familiar with diagnosis and management of CCHD.
机译：背景技术先天性先天性心脏病（CCHD）占先天性心脏病的25％，新生儿的发病率和死亡率很高。目的这项工作的目的是研究CCHD管理中使用的临床资料和可用的治疗方式。对象和方法这是一项从2011年1月开始的为期一年的前瞻性研究，纳入了上埃及索哈格Sohag大学医院新生儿重症监护室（NICU）收治的50例新生儿。所有纳入的患者均接受了全面的临床病史，全面的临床检查，通过脉搏血氧饱和度，血气分析和超声心动图进行初始和频繁的氧饱和度测量。此外，还指出了用于CCHD治疗的治疗方式。结果50例新生儿被诊断患有CCHD，其中39例（78％）是男性，男女之比为3.55：1。出现的平均年龄为11.78±9.4天。在我们的重症监护病房人群中，CCHD频率为9.5％（50/524）。 CCHD最常见的类型是大动脉D型转位（D-TGA）（66％），其次是复杂的CCHD（12％）和左心发育不全综合征（HLHS）（12％），而较不常见的CCHD类型是发育不全右心室（2％）。所有病例均出现中央性紫并需要医疗，而26％的病例进行了球囊房间隔造瘘术。 74％的病例得到了改善，转诊到了更高的中心，而26％的病例在住院期间过期了。结论CCHD是新生儿发病和死亡的主要原因。在我们的研究人群中，CCHD频率显着（9.5％），其中D-TGA是最常见的类型。多数患有CCHD的新生儿通过适当的治疗可以生存。早期诊断和转诊至小儿心脏中心进行适当治疗将改善预后。新生儿科医生和儿科心脏病学家应熟悉CCHD的诊断和管理。

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