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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Angiotensin-converting enzyme (ACE) I/D and bradykinin B2 receptor T/C genes polymorphism in patients with ACE inhibitors-related cough
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Angiotensin-converting enzyme (ACE) I/D and bradykinin B2 receptor T/C genes polymorphism in patients with ACE inhibitors-related cough

机译：ACE抑制剂相关性咳嗽患者血管紧张素转换酶（ACE）I / D 和缓激肽B2受体T / C基因多态性

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Background Angiotensin-converting enzyme (ACE) inhibitors-related cough had been reported to contribute for discontinuation of ACE inhibitors therapy. The role of ACE I/D and bradykinin B2 receptor T/C genes in ACE inhibitors-related cough is still unclear. Objectives To determine ACE I/D and bradykinin B2 receptor T/C genes polymorphisms in patients with ACE-inhibitors-related cough. Subjects and methods An analytical study with cross-sectional design was conducted at Saiful Anwar General Hospital from June 2013 to September 2014. We used the polymerase chain reaction to genotype ACE I/D and bradykinin B2 receptor T/C genes . Data on both ACE I/D and bradykinin B2 receptor T/C genes polymorphisms in cough and non cough group of hypertensive patients treated with ACE inhibitors in our Hospital during the period were analyzed using multiple logistic regression. Moreover, a meta-analysis was performed to summarize findings from other regions. Results A total of 18 patients with cough (21%) and 67 patients without cough (79%) of hypertensive patients treated with ACE inhibitors from our Hospital during the period were analyzed for this study. In our population, no correlation was observed between ACE inhibitors-related cough and both ACE I/D (p?=?0.560) and bradykinin B2 receptor T/C (p?=?0.475) genes polymorphism. However, our meta-analysis of five studies consisting of 267 patients with cough and 346 patients without cough revealed that higher risk of ACE inhibitors-related cough was 1.82-fold associated with T allele of bradykinin B2 receptor T/C gene polymorphism (p?=?0.0310). Conclusions While the evidence in our meta-analysis suggests strong role for bradykinin gene polymorphism in ACE inhibitors-related cough, however, in our population, we did not find any association.
机译：背景技术据报道，与血管紧张素转换酶（ACE）抑制剂有关的咳嗽可导致ACE抑制剂治疗的中断。 ACE I / D和缓激肽B2受体T / C基因在ACE抑制剂相关咳嗽中的作用仍不清楚。目的确定ACE抑制剂相关性咳嗽患者的ACE I / D和缓激肽B2受体T / C基因多态性。对象和方法从2013年6月至2014年9月，在塞弗尔·安瓦尔总医院进行了横断面设计分析研究。我们使用聚合酶链反应对ACE I / D和缓激肽B2受体T / C基因型进行了分析。采用多元logistic回归分析了本院ACE抑制剂治疗的高血压患者咳嗽和非咳嗽组ACE I / D和缓激肽B2受体T / C基因多态性。此外，进行了荟萃分析以总结其他地区的发现。结果本研究共分析了我院ACE抑制剂治疗的18例咳嗽患者（21％）和67例无咳嗽患者（79％）。在我们的人群中，没有发现与ACE抑制剂相关的咳嗽与ACE I / D（p？=？0.560）和缓激肽B2受体T / C（p？=？0.475）基因多态性之间的相关性。但是，我们对包括267例咳嗽患者和346例无咳嗽患者的五项研究进行的荟萃分析显示，与缓激肽B2受体T / C基因多态性的T等位基因相关，与ACE抑制剂相关的咳嗽的高风险是1.82倍。 =？0.0310）。结论虽然我们荟萃分析的证据表明缓激肽基因多态性在ACE抑制剂相关的咳嗽中具有重要作用，但是在我们的人群中，我们没有发现任何关联。

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