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首页> 外文期刊>Iranian red crescent medical journal >Application of Autologous Platelet-Rich Plasma (PRP) on Wound Healing After Caesarean Section in High-Risk Patients
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Application of Autologous Platelet-Rich Plasma (PRP) on Wound Healing After Caesarean Section in High-Risk Patients

机译：自体富血小板血浆（PRP）在高危患者剖宫产术后伤口愈合中的应用

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Platelet-rich plasma (PRP) is a human plasma product enriched by platelets, growth factors, and fibrinogen with high hemostatic and healing properties. Objectives: The aim of this study was to evaluate the effect of autologous PRP on wound healing in high-risk women undergoing cesarean sections. Patients and Methods: In this balanced, randomized, and controlled trial, 140 patients were admitted to Arash women’s hospital, Tehran, Iran from May of 2013 to November of 2014 for elective cesarean surgery. The patients were randomly assigned into two groups. The intervention group received PRP after surgery, whereas the control group received the usual care. All patients were evaluated at baseline, five days, and eight weeks after the cesarean section. The primary endpoint used the REEDA scale for assessing the changes in wound healing. The secondary outcome measures used were the Vancouver scar scale (VSS) and the visual analog scale (VAS). All scale scores were analyzed using a repeated measures test for variance. Results: At the end of study, the PRP group showed a greater reduction in the edema ecchymosed discharge approximation (REEDA) score compared to the control group (85.5% reduction in the PRP group; 72% in the control group) (P < 0.001). Compared with the control group, the PRP group had a significantly greater reduction in the VAN score, beginning on the fifth day after the cesarean section (-0.7, 38% reduction in PRP group; -0.8, 33% in control group) (P < 0.001), and this trend was stable at the end of the eighth week (-0.6, 54% reduction in PRP group; -0.3, 18% in control group). Furthermore, patients treated with PRP experienced a 93% reduction in the VAS score at the end of follow-up, but the control group only observed a 79% reduction (P < 0.001). Conclusions: It seems that applying PRP is an effective therapeutic approach for wound healing, and faster wound healing is expected due to the presence of more platelets and growth factors.
机译：富含血小板的血浆（PRP）是富含血浆，生长因子和纤维蛋白原的人体血浆产品，具有很高的止血和愈合特性。目的：本研究旨在评估自体PRP对剖宫产高危妇女伤口愈合的影响。患者和方法：在这项平衡，随机和对照的试验中，2013年5月至2014年11月，有140例患者被选入伊朗德黑兰Arash妇女医院接受选择性剖宫产手术。将患者随机分为两组。干预组在手术后接受了PRP，而对照组接受了常规护理。在剖腹产后的基线，五天和八周对所有患者进行评估。主要终点使用REEDA量表评估伤口愈合的变化。使用的次要结局指标是温哥华疤痕量表（VSS）和视觉模拟量表（VAS）。使用重复测量检验对所有量表评分进行方差分析。结果：在研究结束时，与对照组相比，PRP组的水肿性瘀斑放电近似值（REEDA）得分降低幅度更大（PRP组降低85.5％;对照组降低72％）（P <0.001） ）。与对照组相比，PRP组从剖宫产后第五天开始，VAN评分明显降低（-0.7，PRP组降低38％;-0.8，对照组33％）（P <0.001），并且这种趋势在第八周结束时是稳定的（-0.6，PRP组降低54％;-0.3，对照组18％）。此外，在随访结束时，接受PRP治疗的患者的VAS评分降低了93％，而对照组仅观察到降低了79％（P <0.001）。结论：应用PRP似乎是一种有效的伤口愈合治疗方法，由于存在更多的血小板和生长因子，伤口愈合有望更快。

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