Cow’s milk allergy is the most common food allergy in children. Symptoms usually involve the skin and the gastrointestinal and respiratory tracts. Gastrointestinal tract manifestations of cow’s milk allergy are nonspecific, and are the only type that can be diagnosed in all age groups. Here, we report a rare case of cow's milk allergy in an infant with hypoalbuminemia and malnutrition. Case Presentation: A nine-month-old girl was admitted to Dr. Sami Ulus maternity and children’s health and diseases training and research hospital, Ankara, Turkey, in September 2013, for weakness and swelling of the legs that had endured for two days. She had bilateral pretibial pitting (+2) edema. Laboratory data revealed albumin at 1.7 g/dL; serum Na, K, urea, creatinin, and alanine-aspartate aminotransferase levels were normal. Her urinary analysis did not reveal proteinuria. Stool samples were normal, and stool steatocrite was negative. Anti-gliadin, anti-endomysium, and anti-tissue transglutaminase antibodies were negative. Cow’s milk allergy was diagnosed due to cow’s milk-specific IgE and skin prick test results. Conclusions: On rare occasions, cow’s milk allergy presents with hypoalbuminemia. When diagnosis is delayed, this allergy may impair the growth and quality of life and may even be life-threatening.
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机译：牛奶过敏是儿童最常见的食物过敏。症状通常涉及皮肤以及胃肠道和呼吸道。牛奶过敏的胃肠道表现是非特异性的，并且是所有年龄组中唯一可诊断的类型。在这里，我们报告了低蛋白血症和营养不良的婴儿对牛奶过敏的罕见情况。病例报告：2013年9月，一名9个月大的女孩因双腿无力和肿胀而被送往土耳其安卡拉的Sami Ulus博士妇幼保健和疾病培训研究医院。她患有双侧胫前凹（+2）水肿。实验室数据显示白蛋白为1.7 g / dL;血清Na，K，尿素，肌酐和丙氨酸-天冬氨酸转氨酶水平正常。她的尿液分析未发现蛋白尿。大便样本正常，大便滑石粉阴性。抗麦醇溶蛋白，抗内胚层和抗组织转谷氨酰胺酶抗体均为阴性。牛奶过敏是由于牛奶中特定的IgE和皮肤点刺测试结果而诊断出来的。结论：在极少数情况下，牛奶过敏会导致低白蛋白血症。如果诊断延迟，这种过敏可能会损害生长和生活质量，甚至可能危及生命。
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