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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Gene frequencies of ABO and Rh(D) blood group alleles in Lagos, South-West Nigeria
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Gene frequencies of ABO and Rh(D) blood group alleles in Lagos, South-West Nigeria

机译：尼日利亚西南部拉各斯ABO和Rh（D）血型等位基因的基因频率

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Background It has been well documented that the ABO and Rhesus remain clinically the most significant blood group systems. There is limited information on the gene frequency of the ABO and Rhesus blood groups from Lagos, South-West Nigeria. Data from this study will be of immense use to the geneticists, biologists, blood transfusion services policy maker and clinicians. Aim of this study This study aims to provide descriptive information on the genetic composition and variation of population in Lagos State, Nigeria, with respect to blood group and Rhesus factor contributing to the existing knowledge. Subjects and methods This study investigated the gene frequencies for the ABO and Rh(D) alleles in a population consisting of different ages in Lagos, Nigeria, over a period spanning 12 years (1998–2009). The 23,832 and 23,764 individuals were typed for ABO and Rh blood groups, respectively. We analyzed the genotypic and allelic frequencies based on Hardy–Weinberg equations. Chi-square goodness-of-fit statistic was calculated to compare observed and expected frequencies and to investigate heterogeneity between years. Results 5504 (23.1%), 5072 (21.3%), 647 (2.7%) and 12,609 (52.9%) were blood groups A, B, AB and O, respectively. Over the period of this study, we observed an overall trend of ABO blood group was O>B>A>AB in both males and females. We also observed that blood group O was the most encountered phenotype while group AB was the least phenotype encountered among the studied population in both genders. This distribution differs significantly ( p <0.05) from those expected under the Hardy–Weinberg law. With regard to the Rh blood group, individuals with Rh positive (DD and Dd) were 0.69 and 0.28. Rh negative (dd) was 0.03. This also showed that Rh(D) positive was the most phenotype observed in this study. This distribution do not differ significantly ( p >0.05) from those expected under the Hardy–Weinberg law. Conclusion Our results demonstrate that there exist genetic variability and polymorphism as regards ABO and Rh blood group among the population sampled. These findings would be useful to geneticists and clinicians when planning to address future health challenges relating blood transfusion and marriage counseling.
机译：背景技术已有大量文献证明，ABO和恒河猴在临床上仍是最重要的血型系统。关于来自尼日利亚西南部拉各斯的ABO和恒河猴血型的基因频率的信息有限。这项研究的数据将对遗传学家，生物学家，输血服务决策者和临床医生大有帮助。本研究的目的本研究旨在提供有关构成现有知识的血型和恒河猴因子的尼日利亚拉各斯州遗传组成和种群变异的描述性信息。受试者和方法这项研究调查了尼日利亚拉各斯不同年龄的人群在12年（1998-2009年）内ABO和Rh（D）等位基因的基因频率。分别为ABO和Rh血型分了23,832和23,764个人。我们基于Hardy-Weinberg方程分析了基因型和等位基因频率。计算卡方拟合优度统计数据，以比较观察到的频率和预期频率，并调查各年之间的异质性。结果A，B，AB和O血型分别为5504（23.1％），5072（21.3％），647（2.7％）和12,609（52.9％）。在本研究期间，我们观察到男性和女性的ABO血型总体趋势为O> B> A> AB。我们还观察到，在两个性别的研究人群中，O型血是最常见的表型，而AB型血是最小的表型。这种分布与哈迪-温伯格定律所预期的分布有显着差异（p <0.05）。关于Rh血型，Rh阳性个体（DD和Dd）分别为0.69和0.28。 Rh负值（dd）为0.03。这也表明Rh（D）阳性是本研究中观察到的最大表型。这种分布与哈迪-温伯格定律下的预期值没有显着差异（p> 0.05）。结论我们的结果表明，在抽样人群中，ABO和Rh血型存在遗传变异和多态性。这些发现对于计划解决与输血和结婚咨询有关的未来健康挑战的遗传学家和临床医生将是有用的。

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