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首页> 外文期刊>International Journal of Dentistry >Variation of Energy in Photobiomodulation for the Control of Radiotherapy-Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients
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Variation of Energy in Photobiomodulation for the Control of Radiotherapy-Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients

机译：光生物调节中能量的变化，以控制放射治疗引起的口腔粘膜炎：在头颈癌患者中的临床研究

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摘要

Oral mucositis (OM) is a frequent and severe adverse effect of therapy against head and neck cancer. Photobiomodulation with the low-power laser is known to be effective against OM, but the diversity of protocols and the possibility of stimulating residual tumor cells are still obstacles. The present study aimed to compare two doses of laser energy delivered to the oral mucosa of patients under oncologic treatment for head and neck cancer, looking for differences in the control of mucositis, as well as in the frequency of tumoral recurrences. Fifty-eight patients undergoing radiotherapy were randomized into two groups, distinguished according to the energy delivered by laser irradiation, namely, 0.25 J and 1.0 J. The groups were compared according to frequency, severity, or duration of OM, as well as the frequency of tumoral recurrences. OM was significantly less frequent in patients receiving 1.0 J of energy, but the groups did not differ regarding severity or duration of OM. Tumoral recurrence also did not vary significantly between the groups. Photobiomodulation with a higher dose of energy (1.0 J versus 0.25 J) is associated with better control of radiotherapy-induced OM and does not significantly increase the risk of neoplastic recurrence.
机译：口腔粘膜炎（OM）是针对头颈癌的常见且严重的不良反应。已知用低功率激光进行光生物调节可有效对抗OM，但方案的多样性和刺激残留肿瘤细胞的可能性仍然是障碍。本研究旨在比较接受头颈癌肿瘤治疗的患者口腔粘膜的两种剂量的激光能量，以寻找对粘膜炎的控制以及肿瘤复发频率的差异。将58例接受放射治疗的患者随机分为两组，根据激光照射的能量分别为0.25 J和1.0 J，并根据OM的频率，严重性或持续时间以及频率对两组进行比较。肿瘤复发。在接受能量为1.0 energyJ的患者中，OM的频率明显降低，但是各组在OM的严重程度或持续时间方面没有差异。两组之间的肿瘤复发也没有显着差异。更高剂量的光生物调节（1.0 J比0.25 J）与更好地控制放疗引起的OM并不会显着增加肿瘤复发的风险。

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