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首页> 外文期刊>International Journal of Dentistry >Variation of Energy in Photobiomodulation for the Control of Radiotherapy-Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients
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Variation of Energy in Photobiomodulation for the Control of Radiotherapy-Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients

机译：放射疗法诱导口腔粘膜炎控制的光生物调节中能量的变异：头颈癌症患者的临床研究

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摘要

Oral mucositis (OM) is a frequent and severe adverse effect of therapy against head and neck cancer. Photobiomodulation with the low-power laser is known to be effective against OM, but the diversity of protocols and the possibility of stimulating residual tumor cells are still obstacles. The present study aimed to compare two doses of laser energy delivered to the oral mucosa of patients under oncologic treatment for head and neck cancer, looking for differences in the control of mucositis, as well as in the frequency of tumoral recurrences. Fifty-eight patients undergoing radiotherapy were randomized into two groups, distinguished according to the energy delivered by laser irradiation, namely, 0.25?J and 1.0?J. The groups were compared according to frequency, severity, or duration of OM, as well as the frequency of tumoral recurrences. OM was significantly less frequent in patients receiving 1.0?J of energy, but the groups did not differ regarding severity or duration of OM. Tumoral recurrence also did not vary significantly between the groups. Photobiomodulation with a higher dose of energy (1.0?J versus 0.25?J) is associated with better control of radiotherapy-induced OM and does not significantly increase the risk of neoplastic recurrence.
机译：口腔粘膜炎（OM）是对头部和颈部癌症的频繁和严重的不良反应。已知具有低功率激光的光致调制对OM有效，但协议的多样性和刺激残留肿瘤细胞的可能性仍然是障碍。本研究旨在将两种剂量的激光能量与头部和颈部癌症的肿瘤治疗下的患者口腔粘膜进行比较，寻找粘膜炎控制的差异，以及肿瘤复发频率。 58名接受放射疗法的患者随机分为两组，根据激光照射输送的能量，即0.25Ω·j和1.0？j。根据OM的频率，严重程度或持续时间以及肿瘤复发的频率进行比较。 OM在接受1.0°的能量患者中的频率显着较低，但是该组对OM的严重程度或持续时间没有不同。肿瘤复发在组之间也没有显着变化。具有较高剂量的能量（1.0×j对0.25≤j）的光致调节与放射治疗诱导的OM的更好控制有关，并且不会显着增加肿瘤复发的风险。

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