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首页> 外文期刊>Isra Medical Journal >Diabetic Dyslipidaemia and Hypolipidaemic Effect of Turmeric in Alloxan-Induced Diabetic Rats Original Research Article
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Diabetic Dyslipidaemia and Hypolipidaemic Effect of Turmeric in Alloxan-Induced Diabetic Rats Original Research Article

机译：糖尿病血脂异常和姜黄对四氧嘧啶致糖尿病大鼠的降血脂作用

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OBJECTIVES: To determine serum lipid lowering effect of turmeric in alloxan-induced diabetic rats.STUDY DESIGN: A Randomized controlled trial (experimental animal study)PLACE AND DURATION: Conducted at Postgraduate Medical Institute Lahore. Approval from ethical committee of animal sciencesof PGMI was obtained before the start of experiment. The study was conducted from 1st September to 30th December, 2014, afterinduction of diabetes.METHODOLOGY: In this study alloxan (intraperitoneal, 150mg/kg body weight) was used to produce animal models of type-I diabetes.The study was conducted on forty five albino rats. Animals were divided into three groups with fifteen animals each (normalcontrol group A, diabetic untreated group B and diabetic group C treated with turmeric powder). Turmeric was given daily orallythrough 5cc disposable syringe (oral gavage method)in a dosage of 300mg/kg body-wt. dissolved in 4 ml distilled water per rat toall the 15 group C diabetic albino rats following one week after induction of diabetes. Blood samples of animals were taken fromthe saphenous vein after overnight fasting at zero day (one week following induction of diabetes in groups B and C), by the end of8th week and by the end of 12th week respectively. Serum lipid profile was measured by direct quantitative method by using thecommercially available Human kits. Analysis of data was done by using SPSS version 18.0.RESULTS: Significantly elevated serum lipid levels (diabetic dyslipidaemia) were found in diabetic animals of group B and C afteralloxan administration. Administration of turmeric for 12 weeks to group C diabetic animals showed significant improvements inserum lipid levels towards normal but not completely.CONCLUSION: Diabetes induces significant alterations in serum lipid profile. Turmeric powder possesses hypolipidaemic effects.
机译：目的：确定姜黄在四氧嘧啶诱导的糖尿病大鼠中的血脂降低作用。研究设计：一项随机对照试验（实验动物研究）地点和时间：在拉合尔研究生医学院进行。实验开始前已获得PGMI动物科学伦理委员会的批准。该研究于2014年9月1日至12月30日，在诱发糖尿病后进行。方法：本研究使用四氧嘧啶（腹膜内，体重150mg / kg）制作I型糖尿病动物模型，该研究共进行了40次。五只白化病大鼠。将动物分为三组，每组十五只（用姜黄粉治疗的正常对照组A，糖尿病未治疗组B和糖尿病C组）。通过5cc一次性注射器（口服灌胃法）每日口服姜黄，剂量为300mg / kg体重。在诱导糖尿病后1周，将每只大鼠溶于4 ml蒸馏水，使15只C组糖尿病白化病大鼠全部溶解。分别在第8周和第12周结束时于零日（在B和C组中诱发糖尿病后一周）禁食过夜后，从大隐静脉抽取动物血样。使用可商购的人试剂盒通过直接定量方法测量血清脂质谱。使用SPSS 18.0版进行数据分析。结果：施用四氧六环后，B组和C组糖尿病动物的血脂水平明显升高（糖尿病性血脂异常）。向C组糖尿病动物施用姜黄12周后，血清脂质水平显着改善，但未达到正常水平。结论：糖尿病可引起血清脂质水平的显着改变。姜黄粉具有降血脂作用。

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