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首页> 外文期刊>eLife journal >The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor
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The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor

机译：基本的亮氨酸拉链转录因子NFIL3指导常见先天淋巴样细胞前体的发育

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The mucus-covered tissues that line the nose, mouth, and the digestive tract play an important role in protecting the body from infection. These mucosal tissues are the first line of defense against any pathogens we inhale or ingest, and help to keep communities of helpful bacteria—such as those that aid digestion—in place so that they can perform their beneficial functions without causing disease. A special group of immune cells called innate lymphoid cells helps to prevent infection in the mucosal tissues and to repair damage to these tissues. There are several different types of innate lymphoid cells, with each type performing a different function. All innate lymphoid cells originate from precursor cells in the bone marrow. Some of these precursor cells had been identified previously, but were able to develop into only some of the different innate lymphoid cell types. Scientists suspected that a precursor cell existed that could develop into all types of innate lymphoid cell, but the identity of this cell had remained elusive. Yu, Wang et al. now identify a precursor cell in the bone marrow that can produce all of the currently known different types of innate lymphoid cells. A protein called NFIL3 coaxes stem cells in the bone marrow into becoming these precursor cells, which only develop into innate lymphoid cells, and not into other immune cell types such as B cells and T cells. Yu, Wang et al. find that NFIL3 causes some of these previously identified precursor cells to become dedicated producers of innate lymphoid cells by regulating another protein called TOX. Furthermore, gene therapy using NFIL3- or TOX-encoding DNA can help to restore normal numbers of innate lymphoid cells in mice whose bone marrow progenitor cells lack the NFIL3 gene. These new details about how bone marrow stem cells develop into innate lymphoid cells may help scientists looking for new ways to treat infections or diseases that hamper the innate immune system.
机译：覆盖鼻子，嘴巴和消化道的粘液覆盖组织在保护人体免受感染中起着重要作用。这些粘膜组织是抵抗我们吸入或摄入的任何病原体的第一道防线，有助于将有益细菌群落（如有助于消化的细菌）保持在适当的位置，以便它们能够发挥有益的功能而不会引起疾病。一类特殊的免疫细胞称为先天淋巴样细胞，有助于预防粘膜组织感染并修复对这些组织的损伤。先天性淋巴样细胞有几种不同的类型，每种类型执行不同的功能。所有先天性淋巴样细胞均起源于骨髓中的前体细胞。这些前体细胞中的一些先前已被鉴定，但仅能发育成一些不同的先天性淋巴样细胞类型。科学家怀疑存在一个可以发展成所有类型的先天性淋巴样细胞的前体细胞，但是这种细胞的身份仍然难以捉摸。于，王等。现在鉴定出骨髓中的前体细胞，该前体细胞可以产生所有当前已知的不同类型的先天淋巴样细胞。一种称为NFIL3的蛋白质哄骗骨髓中的干细胞成为这些前体细胞，这些前体细胞仅发育成先天性淋巴样细胞，而不发育成其他免疫细胞类型，例如B细胞和T细胞。于，王等。发现NFIL3通过调节另一种称为TOX的蛋白质，使这些先前确定的前体细胞中的一些成为先天淋巴样细胞的专门生产者。此外，使用编码NFIL3或TOX的DNA进行基因治疗可以帮助恢复骨髓祖细胞缺乏NFIL3基因的小鼠的先天淋巴样细胞的正常数量。这些关于骨髓干细胞如何发育成先天性淋巴样细胞的新细节可能会帮助科学家寻找新的方法来治疗会阻碍先天性免疫系统的感染或疾病。

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