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Mixing patterns and the spread of close-contact infectious diseases

机译:密切接触型传染病的混合模式和传播

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Surprisingly little is known regarding the human mixing patterns relevant to the spread of close-contact infections, such as measles, influenza and meningococcal disease. This study aims to estimate the number of partnerships that individuals make, their stability and the degree to which mixing is assortative with respect to age. We defined four levels of putative at-risk events from casual (physical contact without conversation) to intimate (contact of a sexual nature), and asked university student volunteers to record details on those they contacted at these levels on three separate days. We found that intimate contacts are stable over short time periods whereas there was no evidence of repeat casual contacts with the same individuals. The contacts were increasingly assortative as intimacy increased. Such information will aid the development and parameterisation of models of close contact diseases, and may have direct use in outbreak investigations.
机译:令人惊讶的是,关于与诸如麻疹,流感和脑膜炎球菌病等紧密接触感染的传播有关的人类混合模式知之甚少。这项研究的目的是估计个人建立的伙伴关系的数量,他们的稳定性以及就年龄而言混合的分类程度。我们将假定的高风险事件定义为四个级别,从偶然的(不进行交谈的身体接触)到亲密的(性接触),并请大学生志愿者记录他们在三天中在这些级别上接触的事件的详细信息。我们发现亲密接触在短期内是稳定的,而没有证据表明与同一个人重复偶然接触。随着亲密关系的增加,接触变得越来越多样化。这些信息将有助于密切接触疾病模型的开发和参数化,并可直接用于暴发调查。

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