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首页> 外文期刊>Endoscopy International Open >Endoscopic management of bleeding gastric varices with N-butyl, 2-cyanoacrylate glue injection in children with non-cirrhotic portal hypertension
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Endoscopic management of bleeding gastric varices with N-butyl, 2-cyanoacrylate glue injection in children with non-cirrhotic portal hypertension

机译：非肝硬化门脉高压患儿胃镜静脉曲张破裂出血的N-丁基-2-氰基丙烯酸酯胶注射治疗

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Background and study aims: In view of the paucity of literature, we carried out this audit to evaluate the safety and efficacy of N- butyl, 2-cynoacrylate glue injection therapy in secondary prophylaxis of gastric varices in children. Patients and methods: Consecutive children (≤?18 years) with non-cirrhotic portal hypertension who presented with bleeding from gastric varices and who had undergone cyanoacrylate glue injection therapy were included. They were evaluated for safety, efficacy and complications. Their long-term outcomes and follow-up were recorded. Results: Over 11 years, 28 children with median age 13 (range, 8 to 18) years (68?% boys), underwent cyanoacrylate glue injection for bleeding gastric varices. In 25 (89?%) cases, extrahepatic portal venous obstruction was the etiology and isolated gastric varices were the source of the bleeding. Primary and secondary gastric variceal bleeding was seen in 11 (39?%) and 17 (61?%) children, respectively. A total 36 sessions with median volume of 2 (range, 1?–?5) mL of glue injections were required (2 sessions in 8 children). Hemostasis was achieved in all and 57?% had gastric variceal obliteration. Two children had early (
机译：背景与研究目的：鉴于文献匮乏，我们进行了此项审核，以评估N-丁基，2-氰基丙烯酸酯胶注射疗法在儿童胃静脉曲张继发性预防中的安全性和有效性。患者和方法：包括连续性儿童（≤18岁），患有非肝硬化性门静脉高压症，其表现为胃底静脉曲张破裂出血并接受了氰基丙烯酸酯胶注射治疗。对他们的安全性，疗效和并发症进行了评估。记录他们的长期结果和随访情况。结果：超过11岁，对28名中位年龄13（8至18岁）儿童（男童占68％）进行了注射氰基丙烯酸酯胶治疗胃静脉曲张破裂出血的研究。在25例（89％）的病例中，肝外门静脉阻塞是病因，孤立的胃静脉曲张是出血的来源。分别在11（39％）和17（61％）儿童中发现原发性和继发性胃静脉曲张破裂出血。总共需要进行36次注射，每次注射胶水的中位数为2（范围为1？–？5）mL（8个孩子2次）。所有患者均达到了止血效果，胃静脉曲张闭塞率为57％。 2名儿童早出血（<1个月），2名儿童晚出血。一个孩子患有胃溃疡。在中位随访24（8？–？98）个月内，有14名儿童接受了手术（12例门体系统分流），有2例失访，1例死亡，其余11例无出血复发结论：氰基丙烯酸酯胶注射液是继发预防非肝硬化门脉高压患儿胃底静脉曲张破裂出血的有效方法。再出血发生率为14％，但与治疗相关的并发症很少见。但是，需要进行大规模的对照临床试验以证实我们的发现。

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