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首页> 外文期刊>Engineering Applications of Computational Fluid Mechanics >Biomechanical Factors Influencing Type B Thoracic Aortic Dissection: Computational Fluid Dynamics Study
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Biomechanical Factors Influencing Type B Thoracic Aortic Dissection: Computational Fluid Dynamics Study

机译：影响B型胸主动脉夹层的生物力学因素：计算流体动力学研究

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AbstractThoracic aortic dissection is a dangerous pathological condition where blood intrudes into the vascular wall, creating an artificial channel, the false lumen. The weakened false lumen wall may rupture, resulting in high mortality. Biomechanical factors investigated are the size of the dissecting aneurysm, the blood pressure, the geometry around the distal tear, a configuration of partial thrombosis, the distance between the tears, and the shear stress. The force acting on the walls of the false lumen will generally become larger with increasing size of the dissection or a higher blood pressure. The effects of shear stress, in terms of the ‘average wall shear stress’ and ‘oscillatory shear index’, are elucidated, with low shear stress reversing in direction over time implying damage to the blood vessel. Clinicians can thus assess the danger of imminent rupture quantitatively. This information will help in the decision regarding surgical interventions.
机译：摘要胸主动脉夹层是一种危险的病理状况，血液侵入血管壁，形成人造通道，即假管腔。虚假的管腔壁变薄可能会破裂，导致高死亡率。研究的生物力学因素是夹层动脉瘤的大小，血压，远端泪液周围的几何形状，部分血栓形成，泪液之间的距离以及剪切应力。随着解剖尺寸的增加或血压的升高，作用在假管腔壁上的力通常会变大。阐明了剪切应力的影响，包括“平均壁剪切应力”和“振荡剪切指数”，随着时间的推移，低剪切应力会反向变化，这意味着对血管的损害。因此，临床医生可以定量评估即将破裂的危险。该信息将有助于做出有关外科手术干预的决定。

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