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首页> 外文期刊>Endocrine journal >Clinical Features of Bone Metastases Resulting from Thyroid Cancer: A Review of 28 Patients over a 20-year Period
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Clinical Features of Bone Metastases Resulting from Thyroid Cancer: A Review of 28 Patients over a 20-year Period

机译：甲状腺癌引起的骨转移的临床特征：20年期间对28例患者的回顾

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References(25) Cited-By(10) Bone is the second most frequent site of metastasis resulting from thyroid cancer. Many studies have investigated clinical features and prognostic factors of distant metastases stemming from thyroid cancer in Western countries. The purpose of this study was to review clinical characteristics of Korean patients with bone metastasis originating from thyroid cancer. Between January 1985 and August 2004, 28 patients with thyroid cancer were diagnosed with bone metastases at the Yonsei Severance Hospital in Seoul, Korea. Their clinical characteristics were analyzed retrospectively. Incidence of bone metastasis from follicular thyroid cancer was 6.8% (9 of 132 patients), and 0.4% (13 of 3,154 patients) from papillary thyroid cancer, with an odds ratio of 17.67 (95% confidence interval; 7.41–42). Twelve patients had no symptoms of bone metastasis. Overall mean number of metastasis sites was 2.6 ± 1.9, and 12 patients had a solitary bone metastasis. Survival rates between the synchronous and metachronous metastasis groups were not significantly different, and the number of metastasis sites did not affect survival. However, the survival of patients that underwent curative treatment was longer than those with palliation (P = 0.0317). In Korea, the overall incidence of bone metastasis resulting from thyroid cancer was less than our expectation. Many patients were asymptomatic, and had a tendency of undergoing less aggressive or palliative treatment, even though the long-term survival of distant metastasis resulting from thyroid cancer with active treatment is relatively good. Further studies of the prognostic factors and effectiveness of various treatments of these patients are needed to enhance survival.
机译：参考文献（25）Cited-By（10）骨骼是甲状腺癌引起的第二常见的转移部位。许多研究已经调查了西方国家源自甲状腺癌的远处转移的临床特征和预后因素。这项研究的目的是审查来自甲状腺癌的韩国骨转移患者的临床特征。在1985年1月至2004年8月之间，韩国首尔延世遣散医院将28例甲状腺癌患者诊断为骨转移。回顾性分析其临床特征。滤泡性甲状腺癌的骨转移发生率为6.8％（132例中的9例），乳头状甲状腺癌的0.4％（3154例中的13例），比值比为17.67（95％置信区间; 7.41-42）。 12名患者没有骨转移的症状。转移部位的总平均数为2.6±1.9，并且12例患者发生了孤立性骨转移。同步转移组和异时转移组之间的生存率没有显着差异，转移部位的数量并不影响生存。然而，接受根治性治疗的患者的生存期比具有姑息治疗的患者（P = 0.0317）更长。在韩国，甲状腺癌引起的骨转移的总体发生率低于我们的预期。尽管积极治疗的甲状腺癌引起的远处转移的长期生存相对较好，但许多患者无症状，并且倾向于较少接受积极或姑息治疗。需要进一步研究这些患者的各种治疗的预后因素和有效性，以提高生存率。

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