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首页> 外文期刊>Endocrine journal >Role of Adrenalectomy in Ectopic ACTH Syndrome
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Role of Adrenalectomy in Ectopic ACTH Syndrome

机译：肾上腺切除术在异位ACTH综合征中的作用

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References(19) Cited-By(3) Evaluation of adrenalectomy in patients diagnosed with ectopic ACTH syndrome was studied. Twenty-three clinical cases diagnosed with ectopic ACTH syndrome were analyzed at Chinese Academy of Medical Sciences and Peking Union Medical College Hospital (PUMCH). Cases consisted of 14 males and 9 females, with mean age of 38 years. All 23 cases had positive clinical, biochemical and radiology evidence for diagnosis of Cushing's syndrome. Sixteen of the 23 cases were treated with total adrenalectomy and the remaining 7 were treated without surgical intervention. Sixteen cases, having no identifiable source of ectopic hormone production, experienced resolution of presenting signs and symptoms after undergoing bilateral or unilateral total adrenalectomy; 1-year survival was 67%, 2-year survival 41% and 5-year survival 15%. In patients treated conservatively without surgical intervention, 1-year survival was 0%. In patients with no identifiable source of ectopic hormone production, bilateral adrenalectomy followed by hormone replacement treatment is effective.
机译：参考文献（19）引用（3）对诊断为异位ACTH综合征的患者进行肾上腺切除术的评估进行了研究。在中国医学科学院和北京协和医院（PUMCH）分析了诊断为异位ACTH综合征的23例临床病例。病例包括14例男性和9例女性，平均年龄为38岁。所有23例临床，生化和放射学证据均能阳性诊断库欣综合征。 23例中有16例接受了全肾上腺切除术治疗，其余7例无需手术干预即可治疗。 16例无异位激素产生来源，经双侧或单侧全肾上腺切除术后症状和体征得到缓解; 1年生存率为67％，2年生存率为41％，5年生存率为15％。在未经手术干预的情况下进行保守治疗的患者中，1年生存率为0％。对于无法确定异位激素产生来源的患者，双侧肾上腺切除术随后进行激素替代治疗是有效的。

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