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首页> 外文期刊>Endocrinology Studies >Protamine-containing insulins are strong risk factors, and human insulin analogues are possible risk factors for insulin autoantibody: case-control study
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Protamine-containing insulins are strong risk factors, and human insulin analogues are possible risk factors for insulin autoantibody: case-control study

机译：含鱼精蛋白的胰岛素是很强的危险因素，人胰岛素类似物可能是胰岛素自身抗体的危险因素：病例对照研究

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Insulin autoantibody is known to cause fluctuation of blood glucose. We examined whether medications for diabetes are risk factors for insulin autoantibody. Especially, we examined the associations between types of insulin and insulin autoantibody. We performed a case-control study. From April 2005 to March 2010, insulin autoantibody was measured 273 times in 217 patients in our hospital. Insulin autoantibody was positive (greater than 10%) 53 times in 19 patients (case), and was negative 220 times in 198 patients (control). Oral hypoglycemic agents were not risk factors for insulin autoantibody; the odds ratio was 0.0. In contrast, insulin use was a significant risk factor for insulin autoantibody; the odds ratio (95% confidence interval) was 56.3 (7.3-432.5). As for the types of insulin and insulin autoantibody, human insulins without protamine were not risk factors; the odds ratio was 0.0. For protamine-containing insulins, the odds ratio and adjusted odds ratio (adjusted by age, gender, and disease: type 1 diabetes mellitus, type 2 diabetes mellitus, and no diabetes) were 35.3 (9.6-129.5) and 29.6 (7.6- 115.4), respectively. For Aspart-containing insulins, they were 6.2 (2.2-17.9) and 3.8 (1.2- 12.0), respectively. For Glargine, they were 3.2 (0.6-16.7) and 1.3 (0.2-8.3), respectively. To decrease the problem of insulin antibody, avoiding the use of protamine-containing insulins and avoiding the use of human insulin analogues might be preferable for the patients with diabetes.
机译：已知胰岛素自身抗体会引起血糖波动。我们检查了糖尿病药物是否是胰岛素自身抗体的危险因素。特别是，我们检查了胰岛素类型与胰岛素自身抗体之间的关联。我们进行了病例对照研究。从2005年4月到2010年3月，我院对217例患者的胰岛素自身抗体进行了273次测量。胰岛素自身抗体在19例患者（病例）中阳性53倍（大于10％），在198例患者（对照）中阴性220倍。口服降糖药不是胰岛素自身抗体的危险因素。比值比为0.0。相反，胰岛素的使用是胰岛素自身抗体的重要危险因素。比值比（95％置信区间）为56.3（7.3-432.5）。至于胰岛素和胰岛素自身抗体的类型，没有鱼精蛋白的人胰岛素不是危险因素。比值比为0.0。对于含鱼精蛋白的胰岛素，比值比和调整后的比值比（按年龄，性别和疾病进行调整：1型糖尿病，2型糖尿病和无糖尿病）分别为35.3（9.6-129.5）和29.6（7.6-115.4） ）， 分别。对于含Aspart的胰岛素，它们分别为6.2（2.2-17.9）和3.8（1.2-12.0）。对于甘精胰岛素，它们分别为3.2（0.6-16.7）和1.3（0.2-8.3）。为了减少胰岛素抗体的问题，对于糖尿病患者，避免使用含鱼精蛋白的胰岛素和避免使用人胰岛素类似物可能是优选的。

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