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首页> 外文期刊>Endoscopy International Open >Efficacy of platelet-rich plasma as a shielding technique after endoscopic mucosal resection in rat and porcine models
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Efficacy of platelet-rich plasma as a shielding technique after endoscopic mucosal resection in rat and porcine models

机译：内镜黏膜切除术在大鼠和猪模型中富血小板血浆作为屏蔽技术的功效

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Background and study aims: The aims were to assess the efficacy of endoscopic application of Platelet-rich plasma (PRP) to prevent delayed perforation and to induce mucosal healing after endoscopic resections. Patients and methods: Colonic induced lesions were performed in rats (n?=?16) and pigs (n?=?4). Animals were randomized to receive onto the lesions saline (control) or PRP. Animals underwent endoscopic follow-up.?Thermal injury was assessed with a 1?–?4 scale: (1) mucosal necrosis; (2) submucosal necrosis; (3) muscularis propria necrosis; and (4) serosal necrosis Results: Saline treatment showed 50?% of mortality in rats (P?=?0.02). Mean ulcerated area after 48 hours and 7 days was significantly smaller with PRP than with saline (0.27?±?0.02?cm2 and 0.08?±?0.01?cm2 vs. 0.56?±?0.1?cm2 and 0.40?±?0.06?cm2; P?
机译：背景和研究目的：目的是评估内镜手术后富血小板血浆（PRP）的内镜应用预防预防穿孔和诱导粘膜愈合的功效。患者和方法：在大鼠（n = 16）和猪（n == 4）中进行结肠诱发的病变。将动物随机接受在损伤处的盐水（对照）或PRP。对动物进行内窥镜随访。热损伤的评分为1〜4等级：（1）粘膜坏死; （2）粘膜下坏死; （3）固有肌坏死; （4）浆膜坏死结果：盐溶液治疗可导致大鼠死亡率的50％（P = 0.02）。使用PRP后48小时和7天的平均溃疡面积明显小于生理盐水（0.27？±？0.02？cm2和0.08？±？0.01？cm2与0.56？±？0.1？cm2和0.40？±？0.06？cm2 ; P ＜＜ 0.001）。 PRP（1.25±±0.46）的热损伤发生率显着低于对照组（2.25±±0.50）。 P≥0.006。猪模型在第1周和第2周时显示出用PRP处理的动物比用盐水的动物黏膜恢复的趋势更高（中位面积（cm2：0.55和0.40对1.32和0.79））。结论：PRP的应用结肠粘膜病变在大鼠和猪模型中显示出强大的愈合特性。

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