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首页> 外文期刊>Endocrine journal >Ultraviolet B activated 1,25(OH)2D affects the level of fibroblast growth factor-23 in human
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Ultraviolet B activated 1,25(OH)2D affects the level of fibroblast growth factor-23 in human

机译：紫外线B激活的1,25（OH）2D影响人类成纤维细胞生长因子23的水平

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References(29) Fibroblast growth factor 23 (FGF-23) is known as a phosphaturic factor regulating phosphate homeostasis. Several studies suggest that dietary phosphate, serum phosphate and 1,25-dihydroxyvitamin D [1,25(OH)2D] are candidate regulators of FGF-23. While the human studies, which modulated the dietary or serum phosphate showed in rather controversial results, manipulation of the active vitamin D definitely affected FGF-23 in animals. This study was conducted to elucidate the relationship between active vitamin D directly stimulated by ultraviolet B (UVB) exposure and FGF-23 level in human. Ten healthy young adults were recruited to get the UVB exposure thrice a week at sub-minimal erythemal dose with gradual increment by 10% only for 4 weeks. Serum calcium, phosphate, mineral-related hormones and bone turnover markers were analyzed before and after the UVB exposure every 4 week for 12 whole weeks. Twenty five-hydroxyvitamin D [25(OH)D] increased by 115% (19.8 ng/mL to 40.5 ng/mL, p 2D increased by 75% (49.9 pg/mL to 64.4 pg/mL, p p 2D with delayed stimulatory effect on FGF-23. This result could support the regulatory loop of 1,25(OH)2D and FGF-23 in human, FGF-23 regulation by 1,25(OH)2D.
机译：参考文献（29）成纤维细胞生长因子23（FGF-23）被称为调节磷酸平衡的磷酸饱和因子。几项研究表明，膳食磷酸盐，血清磷酸盐和1,25-二羟基维生素D [1,25（OH）2D]是FGF-23的候选调节剂。尽管人体研究调节了饮食中的磷酸盐或血清磷酸盐的结果颇具争议，但对活性维生素D的操作无疑会影响动物的FGF-23。进行这项研究是为了阐明受紫外线B（UVB）直接刺激的活性维生素D与人类FGF-23水平之间的关系。招募了十名健康的年轻成年人，使其每周以最低微量红斑剂量三次暴露于UVB中，并仅在4周内逐步增加10％。每隔4周进行UVB暴露前后12周，分析血清钙，磷酸盐，矿物质相关激素和骨转换指标。二十五羟基维生素D [25（OH）D]增加115％（19.8 ng / mL至40.5 ng / mL，p 2D增加75％（49.9 pg / mL至64.4 pg / mL，pp 2D具有延迟的刺激作用）该结果可能支持人体内1,25（OH）2D和FGF-23的调控环，而1,25（OH）2D则支持FGF-23。

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