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首页> 外文期刊>Endocrine journal >Reduced arterial stiffness in patients with acromegaly: non-invasive assessment by the cardio-ankle vascular index (CAVI)
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Reduced arterial stiffness in patients with acromegaly: non-invasive assessment by the cardio-ankle vascular index (CAVI)

机译：肢端肥大症患者的动脉僵硬度降低：通过心踝血管指数（CAVI）进行的非侵入性评估

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References(28) Cited-By(1) In patients with acromegaly, cardiovascular diseases are the most common cause of death. Arterial stiffness is increasingly recognized as a valuable surrogate marker for predicting cardiovascular events. To evaluate the vascular status of acromegalic patients, we used the cardio-ankle vascular index (CAVI) to reflect the arterial stiffness from the heart to the ankles. We analyzed 21 acromegalic patients, comprising five patients with untreated active acromegaly, one patient treated with medication and 15 patients who underwent transsphenoidal surgery. Among the 15 patients with surgery, 10 received additional therapies with dopamine agonists and/or somatostatin analogs. All patients with acromegaly unexpectedly showed significant reductions in the CAVI, indicating reduced arterial stiffness, compared with age- and sex-matched controls, regardless of whether they underwent surgery. There was a significant negative correlation between the CAVI and the serum insulin-like growth factor (IGF)-I level in these patients. Active acromegalic patients were associated with lower CAVI than controlled patients. Sequential measurements of the CAVI and serum IGF-I before and after treatment with octreotide and transsphenoidal surgery revealed that a reduced IGF-I level after treatment was accompanied by CAVI elevation. The present findings indicate that the CAVI is negatively correlated with the serum IGF-I level in acromegaly. These findings are consistent with previous reports indicating that the GH/IGF-I axis reduces peripheral vascular resistance. This non-invasive assessment can reflect the present vascular status and would be a useful marker for evaluation of therapeutic effects in patients with acromegaly.
机译：参考文献（28）被引用（1）在肢端肥大症患者中，心血管疾病是最常见的死亡原因。越来越多的动脉僵硬度被认为是预测心血管事件的有价值的替代指标。为了评估肢端肥大症患者的血管状况，我们使用了心踝血管指数（CAVI）来反映从心脏到脚踝的动脉僵硬度。我们分析了21例肢端肥大症患者，其中包括5例未经治疗的活动性肢端肥大症，1例接受药物治疗的患者和15例行经蝶骨手术的患者。在15名接受手术的患者中，有10名接受了多巴胺激动剂和/或生长抑素类似物的其他治疗。与年龄和性别匹配的对照组相比，所有肢端肥大症患者均出乎意料地显示出CAVI的显着降低，表明动脉僵硬度降低，无论他们是否接受了手术。这些患者的CAVI与血清胰岛素样生长因子（IGF）-I水平呈显着负相关。活动性肢端肥大症患者的CAVI值低于对照组。对奥曲肽和经蝶窦手术治疗前后的CAVI和血清IGF-I进行连续测量，发现治疗后IGF-I水平降低伴有CAVI升高。目前的发现表明，CAVI与肢端肥大症的血清IGF-I水平呈负相关。这些发现与以前的报道一致，表明GH / IGF-I轴降低了周围血管阻力。这项非侵入性评估可以反映当前的血管状况，并将成为评估肢端肥大症患者治疗效果的有用标志。

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