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首页> 外文期刊>Endocrine journal >Adipsia increases risk of death in patients with central diabetes insipidus
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Adipsia increases risk of death in patients with central diabetes insipidus

机译：脂肪会增加中枢性尿崩症患者的死亡风险

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References(16) Cited-By(7) Central diabetes insipidus (CDI) is caused by deficiency of arginine vasopressin, an antidiuretic hormone. Patients with CDI manifest polyuria which is usually compensated for by increases in water intake. However, some patients are not able to sense thirst due to the destruction of osmoreceptors in the hypothalamus. These adipsic CDI patients are easily dehydrated and the consequent dehydration could be life-threatening. The objective of this study was to investigate the prognosis of adipsic CDI patients. We have reviewed 149 patients with CDI in three hospitals using databases of the electronic medical recording systems, and examined whether adipsia could affect the morbidity and mortality in CDI patients with multivariable analyses. Twenty-three patients with CDI were adipsic while the remaining 126 patients were non-adipsic. The multivariate analyses showed that the incidence of serious infections which required hospitalization was significantly higher in the adipsic CDI patients compared to that in non-adipsic CDI patients (p 0.001). A total of 6 patients with CDI died during the follow-up (median duration; 60 months, range 1 to 132 months). Four of them were adipsic, three of whom died of infection. The statistical analyses revealed that the risk of death in adipsic CDI patients was significantly higher than in non-adipsic patients (p =0.007). It is thus suggested that adipsic CDI patients were susceptible to serious infections which could be the causes of death.
机译：参考文献（16）（7）被引用的中枢性尿崩症（CDI）是由抗利尿激素精氨酸加压素的缺乏引起的。 CDI患者表现为多尿症，通常可通过增加饮水量来弥补。然而，由于下丘脑中渗透压感受器的破坏，一些患者无法感觉到口渴。这些脂肪性CDI患者很容易脱水，因此脱水可能危及生命。这项研究的目的是调查脂肪性CDI患者的预后。我们已经使用电子病历系统的数据库审查了三家医院的149名CDI患者，并通过多变量分析研究了肥胖是否会影响CDI患者的发病率和死亡率。 CDI患者23例为脂肪性，其余126例为非脂肪性。多元分析表明，与非脂肪性CDI患者相比，脂肪性CDI患者需要住院治疗的严重感染发生率显着更高（p <0.001）。随访期间共有6例CDI患者死亡（中位持续时间; 60个月，范围1至132个月）。他们中有四个是己经，其中三个死于感染。统计分析表明，脂肪性CDI患者的死亡风险显着高于非脂肪性患者（p = 0.007）。因此，建议脂肪性CDI患者易受严重感染的影响，这可能是导致死亡的原因。

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