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首页> 外文期刊>Endocrine journal >Histopathological Features of Atrophic Thyroiditis with Blocking Type-TSH Binding Inhibitor Immunoglobulins
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Histopathological Features of Atrophic Thyroiditis with Blocking Type-TSH Binding Inhibitor Immunoglobulins

机译：萎缩性甲状腺炎与TSH型结合抑制剂免疫球蛋白的组织病理学特征

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References(14) Cited-By(6) To investigate the histopathological features of atrophic thyroiditis (AT) with blocking type-TSH binding inhibitor Immunoglobulins (TBII), the present morphological observations were carried out employing additional immunohistochemical procedures. Moreover, these were compared with examples of goitrous Hashimoto's thyroiditis showing negative TBII (HT). There exist apparent differences between AT and HT. In particular, significant follicular atrophy with epithelial flattening including decreased positive staining of the follicular epithelial cells for thyroglobulin in AT was characteristically observed. These results suggest that the mechanism for the development of hypothyroidism in AT with blocking type-TBII might be due to suppression of thyroid cell function through the inhibition of endogenous TSH stimulation by the blocking antibody with subsequent epithelial degenerative destruction.
机译：参考文献（14）引用（6）为了研究萎缩性甲状腺炎（AT）与阻断型TSH结合抑制剂免疫球蛋白（TBII）的组织病理学特征，采用其他免疫组织化学方法进行了目前的形态学观察。此外，将它们与显示阴性TBII（HT）的甲状腺肿病桥本甲状腺炎的例子进行了比较。 AT和HT之间存在明显的差异。特别地，特征性地观察到显着的卵泡萎缩和上皮变平，包括AT中甲状腺球蛋白的卵泡上皮细胞阳性染色降低。这些结果表明，具有阻断型TBII的AT中甲状腺功能减退症的发展机制可能是由于通过阻断抗体抑制内源性TSH刺激并随后上皮变性退化而抑制了甲状腺细胞功能。

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