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Predictive Modelling of Heavy Metal-Metal Interactions in Environmental Setting: Laboratory Simulative Approach

机译：环境中重金属与金属相互作用的预测模型：实验室模拟方法

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Aquatic ecosystem pollution by heavy metals is a global problem and requires proactive measures and techniques in tackling the scourge. Exposure to multiple contaminants in water environment now displaces the single action of pollutants and creates a challenge for complex mixture contact management. Heavy metals at individual low acting concentrations can elicit higher toxicity on interactions with other environmental toxicants. In this study, Clarias gariepinus was exposed to the mixture of zinc and copper at predetermined ratio of 1:1 and 1:2 based on 96hLC50 index and binary interactive dynamics of the two metals calculated using the synergistic ratio model. Following the exposure, the 9hLC50 values were 84.683 mg/l and 45.875 mg/L for ratios 1:1 and 1:2, respectively. Physiological responses such as rapid opercula movement, frequent gulping of air and neurological symptoms like jerking movements, frightening and loss of balance were observed throughout the experimental period. There were antagonistic and synergistic reactions between the metals at the two combinatorial ratios. Antagonism occurs when the metals were mixed at the ratio of 1:1 and synergism at the ratio of 1:2. We therefore recommend that joint action toxicity of metals should be taken into consideration in fixing environmental safe limits for heavy metals in order to have a complete protection of aquatic ecosystems.
机译：重金属对水生生态系统的污染是一个全球性问题，需要采取积极的措施和技术来应对这一祸害。现在，暴露于水环境中的多种污染物会取代污染物的单一作用，并给复杂的混合物接触管理带来挑战。个别低浓度的重金属可与其他环境毒物相互作用而引起更高的毒性。在这项研究中，基于96hLC 50 指数，并以协同作用计算的两种金属的二元相互作用动力学，将Clarias gariepinus以预定的1：1和1：2比例暴露于锌和铜的混合物中比率模型。暴露后，比例为1：1和1：2的9hLC 50 值分别为84.683 mg / l和45.875 mg / L。在整个实验过程中，观察到生理反应，例如快速的oper盖运动，频繁的食道吞咽和神经系统的症状，如抽搐，恐惧和失去平衡。在两种组合比率的金属之间存在拮抗和协同反应。当金属以1：1的比例混合，协同作用以1：2的比例混合时，会发生拮抗作用。因此，我们建议在确定重金属的环境安全限值时应考虑金属的共同作用毒性，以便对水生生态系统进行全面保护。

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