• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Epigenetics & Chromatin >A role for non-coding Tsix transcription in partitioning chromatin domains within the mouse X-inactivation centre
【24h】

A role for non-coding Tsix transcription in partitioning chromatin domains within the mouse X-inactivation centre

机译：非编码Tsix转录在小鼠X灭活中心内的染色质结构域划分中的作用

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Delimiting distinct chromatin domains is essential for temporal and spatial regulation of gene expression. Within the X-inactivation centre region (Xic), the Xist locus, which triggers X-inactivation, is juxtaposed to a large domain of H3K27 trimethylation (H3K27me3). Results We describe here that developmentally regulated transcription of Tsix, a crucial non-coding antisense to Xist, is required to block the spreading of the H3K27me3 domain to the adjacent H3K4me2-rich Xist region. Analyses of a series of distinct Tsix mutations suggest that the underlying mechanism involves the RNA Polymerase II accumulating at the Tsix 3'-end. Furthermore, we report additional unexpected long-range effects of Tsix on the distal sub-region of the Xic, involved in Xic-Xic trans-interactions. Conclusion These data point toward a role for transcription of non-coding RNAs as a developmental strategy for the establishment of functionally distinct domains within the mammalian genome.
机译：背景界定不同的染色质结构域对于基因表达的时间和空间调控至关重要。在X灭活中心区域（Xic）中，触发X灭活的Xist基因座与H3K27三甲基化的大区域（H3K27me3）并置。结果我们在这里描述，需要阻止Tsix的发育受调控的转录，这是对Xist的至关重要的非编码反义，以阻止H3K27me3结构域向邻近的H3K4me2富集的Xist区的扩散。对一系列不同的Tsix突变的分析表明，潜在的机制涉及RNA聚合酶II积累在Tsix 3'末端。此外，我们报告了Tsix对Xic的远端子区域的其他意想不到的远程影响，参与Xic-Xic的交互作用。结论这些数据表明非编码RNA的转录作为在哺乳动物基因组内建立功能不同域的发展策略的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号