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Trans-generational epigenetic regulation of C. elegans primordial germ cells

机译：秀丽隐杆线虫原始生殖细胞的跨代表观遗传调控

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Background The processes through which the germline maintains its continuity across generations has long been the focus of biological research. Recent studies have suggested that germline continuity can involve epigenetic regulation, including regulation of histone modifications. However, it is not clear how histone modifications generated in one generation can influence the transcription program and development of germ cells of the next. Results We show that the histone H3K36 methyltransferase maternal effect sterile (MES)-4 is an epigenetic modifier that prevents aberrant transcription activity in Caenorhabditis elegans primordial germ cells (PGCs). In mes-4 mutant PGCs, RNA Pol II activation is abnormally regulated and the PGCs degenerate. Genetic and genomewide analyses of MES-4-mediated H3K36 methylation suggest that MES-4 activity can operate independently of ongoing transcription, and may be predominantly responsible for maintenance methylation of H3K36 in germline-expressed loci. Conclusions Our data suggest a model in which MES-4 helps to maintain an 'epigenetic memory' of transcription that occurred in germ cells of previous generations, and that MES-4 and its epigenetic product are essential for normal germ cell development.
机译：背景技术种系保持代代相继的过程一直是生物学研究的重点。最近的研究表明，种系连续性可能涉及表观遗传调控，包括对组蛋白修饰的调控。然而，尚不清楚一代人中产生的组蛋白修饰如何影响下一代人的转录程序和生殖细胞的发育。结果我们显示，组蛋白H3K36甲基转移酶母体作用不育（MES）-4是一种表观遗传修饰剂，可防止秀丽隐杆线虫原始生殖细胞（PGC）中的异常转录活性。在mes-4突变体PGC中，RNA Pol II的激活受到异常调节，PGC退化。 MES-4介导的H3K36甲基化的遗传和全基因组分析表明，MES-4活性可以独立于正在进行的转录而运作，并且可能主要负责维持种系表达基因座中H3K36的甲基化。结论我们的数据提出了一个模型，其中MES-4有助于维持在前代生殖细胞中发生的转录的“表观记忆”，而MES-4及其表观遗传产物对于正常生殖细胞的发育至关重要。

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