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首页> 外文期刊>Environmental Health: A Global Access Science Source >Association of placenta organotin concentrations with growth and ponderal index in 110 newborn boys from Finland during the first 18 months of life: a cohort study
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Association of placenta organotin concentrations with growth and ponderal index in 110 newborn boys from Finland during the first 18 months of life: a cohort study

机译：队列研究：110名芬兰新生婴儿中胎盘有机素浓度与生长和子宫指数的关系：一项队列研究

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Background Humans are exposed to tributyltin (TBT), previously used as an antifouling paint in ships, mainly through fish consumption. As TBT is a known obesogen, we studied the association of placenta TBT and other organotin compounds (OTCs) with ponderal index (PI) and growth during the first 18 months of life in boys. Methods In a prospective Finnish study, 110 placenta samples were collected from mothers of boys born in 1997–1999 with (n?=?55) and without (n?=?55) cryptorchidism. To account for the original study design, linear regression, weighted for sampling fractions of boys with (121/55) and without (5677/55) cryptorchidism from the total cohort, was used to study the association between placenta OTCs and children’s weight, length, growth rates and PI up to 18 months of age. Results Placenta TBT concentrations were above the limit of quantification (LOQ) in 99% of the samples. However, monobutyltin (MBT), dibutyltin (DBT) and triphenyltin (TPhT) concentrations were below LOQ in 90%, 35% and 57% of samples, respectively. Placenta TBT was positively associated (p?=?0.024) with weight gain during the first three months of life, but no other significant associations were observed for weight or length gain. Also, no significant associations between placenta OTC concentrations and child length, weight or PI at any time point were found. Conclusions We observed a trend towards higher weight gain from birth to 3 months of age with increasing placenta TBT concentration. These results should be interpreted with caution because obesogenic effects in animal experiments were seen after in-utero TBT exposures to doses that were orders of magnitude higher. Also the number of study subjects included in this study was limited.
机译：背景技术人类暴露于三丁基锡（TBT）中，三丁基锡以前是船上的防污涂料，主要是通过食用鱼类。由于TBT是一种已知的致肥胖剂，因此我们研究了胎盘TBT和其他有机锡化合物（OTC）与男孩生命中头18个月的总指标（PI）和生长的关系。方法在一项前瞻性芬兰研究中，从1997-1999年出生的男孩中，有（n？=？55）和没有（n？=？55）隐睾症的母亲收集了110份胎盘样本。为了说明原始研究设计，使用线性回归对来自总队列的有（121/55）和没有（5677/55）隐睾的男孩的抽样分数进行加权，以研究胎盘OTC与儿童体重，身长之间的关系。 ，增长率和18岁以下的PI。结果在99％的样品中胎盘TBT浓度均高于定量极限（LOQ）。但是，分别在90％，35％和57％的样品中，单丁基锡（MBT），二丁基锡（DBT）和三苯基锡（TPhT）的浓度低于LOQ。胎盘TBT在生命的头三个月与体重增加呈正相关（p≤0.024），但体重或身长增加未见其他显着相关性。而且，在任何时间点都未发现胎盘OTC浓度与儿童身高，体重或PI之间有显着关联。结论我们观察到随着胎盘TBT浓度的增加，从出生到3个月大的体重增加趋势。应谨慎解释这些结果，因为在子宫内TBT暴露剂量高出几个数量级后，在动物实验中发现了致肥胖作用。同样，这项研究中包括的研究对象的数量是有限的。

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