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Environmental influences on the female epigenome and behavior

机译:环境对女性表观基因组和行为的影响

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Environmental factors have long-lasting effects on brain development and behavior. One way experiences are propagated is via epigenetic modifications to the genome. Environmentally driven epigenetic modifications show incredible brain region- and sex-specificity, and many brain regions affected are ones involved in maternal behavior. In rodent models, females are typically the primary caregiver and thus, any environmental factors that modulate the epigenotype of the mother could have consequences for her current and future offspring. Here, we review evidence of the susceptibility of the female epigenome to environmental factors, with a focus on brain regions involved in maternal behavior. Accordingly, implications for interventions that target the mother’s epigenome and parenting behavior are discussed.
机译:环境因素对大脑发育和行为具有长期影响。经验传播的一种方式是通过对基因组的表观遗传修饰。由环境驱动的表观遗传修饰显示出令人难以置信的大脑区域和性别特异性,并且受影响的许多大脑区域都与孕产妇行为有关。在啮齿动物模型中,雌性通常是主要的照料者,因此,任何影响母亲表观基因型的环境因素都可能对她现在和将来的后代产生影响。在这里,我们回顾了女性表观基因组易受环境因素影响的证据,重点是与母亲行为有关的大脑区域。因此,讨论了针对母亲表观基因组和育儿行为的干预措施的含义。

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