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首页> 外文期刊>Environmental Epigenetics >Environmental enrichment as an intervention for adverse health outcomes of prenatal stress
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Environmental enrichment as an intervention for adverse health outcomes of prenatal stress

机译：丰富环境以干预产前压力对健康的不良影响

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Prenatal stress (PS) has complex neurological, behavioural and physiological consequences for the developing offspring. The phenotype linked to PS usually lasts into adulthood and may even propagate to subsequent generations. The often uncontrollable exposure to maternal stress and the lasting consequences emphasize the urgent need for treatment strategies that effectively reverse stress programming. Exposure to complex beneficial experiences, such as environmental enrichment (EE), is one of the most powerful therapies to promote neuroplasticity and behavioural performance at any time in life. A small number of studies have previously used EE to postnatally treat consequences of PS in the attempt to reverse deficits that were primarily induced in utero . This review discusses the available data on postnatal EE exposure in prenatally stressed individuals. The goal is to determine if EE is a suitable treatment option that reverses adverse consequences of stress programming and enhances stress resiliency. Moreover, this review discusses data with respect to relevant hypotheses including the cumulative stress and the mismatch hypotheses. The articles included in this review emphasize that EE reverses most behavioural, physiological and neural deficits associated with PS. Differing responses may be dependent on the timing and variability of stress and EE, exercise, and potentially vulnerable and resilient phenotypes of PS. Results from this study suggest that enrichment may provide an effective therapy for clinical populations suffering from the effects of PS or early life trauma.
机译：产前压力（PS）对发育中的后代具有复杂的神经，行为和生理后果。与PS相关的表型通常持续到成年，甚至可能传播到后代。经常无法控制的孕产妇压力暴露和持久后果强调了迫切需要有效逆转压力编程的治疗策略。接触复杂的有益经验，例如环境富集（EE），是在生活中任何时候促进神经可塑性和行为表现的最有效疗法之一。少数研究以前使用EE来产后治疗PS的后果，试图扭转主要由子宫引起的缺陷。这篇评论讨论了产前紧张个体在产后EE暴露方面的可用数据。目的是确定EE是否是一种合适的治疗选择，可以逆转压力编程的不良后果并增强压力弹性。此外，本篇文章讨论了有关假设的数据，包括累积压力和失配假设。这篇综述中的文章强调，EE可逆转与PS相关的大多数行为，生理和神经功能障碍。不同的反应可能取决于压力和EE的时间和变异性，运动以及PS的潜在脆弱和有弹性的表型。这项研究的结果表明，富集可能为患有PS或早期生命创伤的临床人群提供有效的治疗方法。

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