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首页> 外文期刊>Biological research for nursing >The Effects of Enriched Environmental Intervention on the Parturition Outcome and Filial Health of Pregnant Mice With Chronic Pain
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The Effects of Enriched Environmental Intervention on the Parturition Outcome and Filial Health of Pregnant Mice With Chronic Pain

机译：富含环境干预对慢性疼痛孕鼠分娩结果和孝疗法的影响

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摘要

Chronic pain (CP) adversely impacts people's health. However, the influence of CP on pregnant women and their fetuses remains unclear. Few reasonable interventions have been offered to these women. This study aimed to examine the effects of enriched environmental intervention (EEI) on the delivery outcome and offspring health of pregnant mice with CP. Forty pregnant mice were equally and randomly divided into four groups (control, sham, CP, and CP + EEI). Monoarthritis was induced by subcutaneous injection of the complete Freund's adjuvant (100 g/100 l) into the left hind paw of mice on Day 0 of gestation. Sham mice received 100 mu l of sterile phosphate-buffered saline subcutaneously. General health status and delivery outcomes of pregnant mice and general physical status, growth, and development of offspring were observed and compared between groups. CP mice exhibited less weight gain, higher rate of premature delivery, smaller litter size, lower live birth rate, lower filial birth weight, shorter filial tail length, and lower filial rates of achieving righting reflex and crawling compared to mice in the control/sham/CP + EEI groups. There were no significant differences between mice in the CP + EEI group and those in the control and sham groups. CP during pregnancy led to serious adverse impacts on both the mother and fetus mice in this study, and EEI was an effective treatment for these effects.
机译：慢性疼痛（CP）对人们的健康产生不利影响。然而，CP对孕妇及其胎儿的影响仍然不清楚。这些妇女提供了很少合理的干预措施。本研究旨在探讨富集环境干预（EEI）对CP怀孕老鼠的递送结果和后代健康的影响。四十个妊娠小鼠同样和随机分为四组（对照，假，CP和CP + EEI）。通过皮下注射完整的弗氏佐剂（100g / 100l）在妊娠期第0天诱导单细胞炎。假小鼠皮下接受100μl无菌磷酸盐缓冲盐水。观察到一般健康状况和妊娠小鼠的递送结果，并在群体之间进行了比较并比较了后代的一般身体状况，增长和发展。 CP小鼠的重量增益较少，过早递送速度较高，凋落率较小，较低的活率，较低的胫骨出生体重，较低的孝尾长，与控制/假目的小鼠相比，实现右侧反射和爬行的较低档案/ cp + EEI组。 CP + EEI组小鼠与控制和假组合没有显着差异。妊娠期间CP导致本研究中对母亲和胎儿小鼠的严重不利影响，并且EEI对这些效果有效治疗。

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