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首页> 外文期刊>Environmental Epigenetics >Low maternal adherence to a Mediterranean diet is associated with increase in methylation at the MEG3-IG differentially methylated region in female infants
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Low maternal adherence to a Mediterranean diet is associated with increase in methylation at the MEG3-IG differentially methylated region in female infants

机译：母亲对地中海饮食的依从性低与女婴MEG3-IG甲基化差异区域的甲基化增加有关

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摘要

Diet is dictated by the surrounding environment, as food access and availability may change depending on where one lives. Maternal diet during pregnancy is an important part of the in utero environment, and may affect the epigenome. Studies looking at overall diet pattern in relation to DNA methylation have been lacking. The Mediterranean diet is known for its health benefits, including decreased inflammation, weight loss, and management of chronic diseases. This study assesses the association between maternal adherence to a Mediterranean diet pattern during pregnancy and infant DNA methylation at birth. Mediterranean diet adherence in early pregnancy was measured in 390 women enrolled in the Newborn Epigenetic Study, and DNA methylation was assessed in their infants at birth. Multinomial logistic regression was used to assess the association between adherence to a Mediterranean diet and infant methylation at the MEG3 , MEG3-IG , pleiomorphic adenoma gene-like 1, insulin-like growth factor 2 gene , H19, mesoderm-specific transcript, neuronatin, paternally expressed gene 3 , sarcoglycan and paternally expressed gene 10 regions, measured by pyrosequencing. Infants of mothers with a low adherence to a Mediterranean diet had a greater odds of hypo-methylation at the MEG3-IG differentially methylated region (DMR). Sex-stratified models showed that this association was present in girls only. This study provides early evidence on the association between overall diet pattern and methylation at the 9 DMRs included in this study, and suggests that maternal diet can have a sex-specific impact on infant DNA methylation at specific imprinted DMRs.
机译：饮食是由周围环境决定的，因为食物的获取和可获得性可能会根据一个人的住所而改变。怀孕期间的孕妇饮食是子宫环境的重要组成部分，并可能影响表观基因组。缺乏有关与DNA甲基化有关的总体饮食模式的研究。地中海饮食以其健康益处而著称，包括减少炎症，减轻体重和控制慢性病。这项研究评估了孕妇在怀孕期间坚持地中海饮食模式与出生时婴儿DNA甲基化之间的关系。对390名参加新生儿表观遗传研究的妇女进行了妊娠早期地中海饮食依从性的评估，并评估了其婴儿出生时的DNA甲基化。多项逻辑回归用于评估地中海饮食的依从性与婴儿甲基化在MEG3，MEG3-IG，多态性腺瘤样基因1，胰岛素样生长因子2基因，H19，中胚层特异性转录本，神经素，焦磷酸测序法测定父本表达的基因3，肌聚糖和父本表达的基因10个区域。对地中海饮食的依从性较低的母亲的婴儿在MEG3-IG差异甲基化区域（DMR）发生低甲基化的可能性更高。按性别分层的模型显示，这种关联仅存在于女孩中。这项研究提供了有关这项研究中包括的9种DMR的总体饮食模式与甲基化之间关联的早期证据，并建议孕妇饮食可以对特定印迹DMR的婴儿DNA甲基化产生性别特异性影响。

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