Non-genomic transmission of longevity between generations: potential mechanisms and?evidence across species

Alexander M. Vaiserman; Alexander K. Koliada; Randy L. Jirtle

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Non-genomic transmission of longevity between generations: potential mechanisms and?evidence across species

机译：两代人之间寿命的非基因组传递：物种间的潜在机制和证据

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Accumulating animal and human data indicate that environmental exposures experienced during?sensitive developmental periods may strongly influence risk of adult disease. Moreover, the effects triggered by developmental environmental cues can be transgenerationally transmitted, potentially affecting offspring health outcomes. Increasing?evidence suggests a central role of epigenetic?mechanisms (heritable alterations in gene expression occurring without changes in underlying DNA sequence) in mediating these effects. This review summarizes the findings from animal models, including worms, insects, and rodents, and also from human studies, indicating that lifespan and longevity-associated characteristics can be transmitted across generations via non-genetic factors.

机译：越来越多的动物和人类数据表明，在敏感的发育时期经历的环境暴露可能会强烈影响成年疾病的风险。而且，由发育环境提示引发的影响可以通过世代传播，可能影响后代的健康状况。越来越多的证据表明，表观遗传机制（在不改变基础DNA序列的情况下发生基因表达的可遗传改变）在介导这些作用中起着核心作用。这篇综述总结了包括蠕虫，昆虫和啮齿动物在内的动物模型的发现，以及来自人类研究的结果，表明寿命和寿命相关的特征可以通过非遗传因素传给几代人。

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《Epigenetics & Chromatin》 |2017年第1期|共页
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Alexander M. Vaiserman; Alexander K. Koliada; Randy L. Jirtle;
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中图分类遗传学;
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机译：注意的不同机制：来自事件相关电位和个体差异的证据。
6. Non-genomic transmission of longevity between generations: potential mechanisms and evidence across species [O] . Alexander M. Vaiserman, Alexander K. Koliada, Randy L. Jirtle 2017

机译：两代人之间寿命的非基因组传递：物种间的潜在机制和证据
7. Non-genomic transmission of longevity between generations: potential mechanisms and evidence across species [O] . Alexander M. Vaiserman, Alexander K. Koliada, Randy L. Jirtle 2017

机译：几代人之间的寿命非基因组传输：潜在的机制和跨物种的证据

Non-genomic transmission of longevity between generations: potential mechanisms and?evidence across species

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