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首页> 外文期刊>Epidemiology and infection >Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections
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Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections

机译：事先接触人类甲型流感病毒中发现的免疫原性肽可能会影响禽流感H5N1和H7N9病毒感染病例的年龄分布

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摘要

The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The median age of infected populations is substantially younger for H5N1 virus (26 years) compared with H7N9 virus (63 years). Population susceptibility to infection with seasonal influenza is understood to be influenced by cross-reactive CD8+ T cells directed towards immunogenic peptides derived from internal viral proteins which may provide some level of protection against further influenza infection. Prior exposure to seasonal influenza peptides may influence the age-related infection patterns observed for H5N1 and H7N9 viruses. A comparison of relatedness of immunogenic peptides between historical human strains and the two avian emerged viruses was undertaken for a possible explanation in the differences in age incidence observed. There appeared to be some relationship between past exposure to related peptides and the lower number of H5N1 virus cases in older populations, however the relationship between prior exposure and older populations among H7N9 virus patients was less clear.
机译：尽管在中国感染的人类H5N1和H7N9禽流感病毒的流行病学有所不同，但两种病毒都是禽类重配体，它们从一个共同的祖先H9N2继承了六个内部基因。与H7N9病毒（63岁）相比，H5N1病毒（26岁）的感染人群中位年龄要年轻得多。人群对季节性流感感染的敏感性被理解为受交叉反应性CD8 + T细胞的影响，该CD8 + T细胞针对源自内部病毒蛋白的免疫原性肽，可以为进一步的流感感染提供一定程度的保护。事先接触季节性流感肽可能会影响针对H5N1和H7N9病毒观察到的与年龄有关的感染模式。比较了人类历史菌株和两种禽流感病毒之间的免疫原性肽的相关性，以解释观察到的年龄发病率差异。过去暴露于相关肽与老年人群中H5N1病毒病例数减少之间似乎存在某种关系，但是在H7N9病毒患者中，先前暴露与老年人群之间的关系尚不清楚。

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